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Herbsmith Rx Si Shen San is a classical Chinese herbal formula recommended by holistic veterinarians to warm and tonify the spleen and kidney, bind the intestines, and address chronic loose stool in dogs, cats, and horses. Comparable to Four Miracle Powder and Four Immortals, it warms and tonifies the spleen and kidney, binds up the intestines, and stops diarrhea. Well suited for pets and horses presenting with spleen and kidney yang deficiency patterns characterized by chronic or recurring loose stool, unformed stool, or early morning diarrhea arising from insufficient kidney yang failing to warm and steam the spleen, and a cold and deficient spleen failing to transform and transport fluids and food, with signs such as chronic loose stool that worsens with cold or in the early morning, undigested food in the stool, fatigue, cold sensitivity, pale tongue, and general signs of yang deficiency in the lower and middle burners. Available as a concentrated powder mixed into food; cats and dogs use the Canine Blend, while horses use the Equine/Horse Blend. Dosing varies by species and body weight, and your authorizing veterinarian will provide specific guidance.
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For Dogs (Canine Blend Powder):
For Cats (Canine Blend Powder): ¼ tsp twice daily, or as prescribed
For Horses (Equine/Horse Blend, 1,000 lb horse): Two tablespoons twice daily for 20 days, then two tablespoons once daily in grain. If the horse initially refuses, start with a small amount mixed into grain and gradually increase until the horse is accustomed to the taste. Most horses will readily accept the herbs in their grain.
Active Ingredients: Bu Gu Zhi (Fructus Psoraleae Corylifoliae), Wu Zhu Yu (Fructus Evodiae Rutaecarpae), Rou Dou Kou (Semen Myristicae Fragrantis), Wu Wei Zi (Fructus Schisandrae Chinensis)
Inactive Ingredient: Flaxseed
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Si Shen San is a four-herb formula that addresses spleen and kidney yang deficiency with intestinal cold and deficiency through a tightly focused combination of a principal kidney yang and spleen warmer, a middle burner cold disperser, an intestinal astringent and spleen warmer, and a consolidating and astringent essence preserver:
Si Shen San contains strongly warming herbs including Bu Gu Zhi, Wu Zhu Yu, and Rou Dou Kou, which have significant effects on digestive motility, intestinal function, and potentially hepatic enzyme pathways. Pets currently on antidiarrheal medications, motility-modifying drugs, immunosuppressive medications, or hepatically metabolized pharmaceuticals should use this formula under veterinary supervision, as the warming and astringent herbs may have additive or counteracting effects with pharmaceutical antidiarrheal agents, and herb-drug interaction research in dogs, cats, and horses remains limited.
Medication categories warranting extra caution include antidiarrheal or antispasmodic medications, motility-modifying drugs, immunosuppressive medications, hepatically metabolized pharmaceuticals, and any medications where changes in intestinal motility or absorption could affect therapeutic monitoring. Your authorizing veterinarian can determine appropriateness based on your animal's condition, current medications, and laboratory results.
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In Traditional Chinese Veterinary Medicine, Si Shen San is indicated for spleen and kidney yang deficiency with intestinal cold and deficiency, presenting as chronic or recurring loose stool, unformed stool, early morning diarrhea, undigested food in the stool, cold sensitivity, fatigue, and general signs of yang deficiency in the lower and middle burners. Comparable to Four Miracle Powder and Four Immortals, it is one of the primary TCVM formulas for the pattern of chronic loose stool driven by kidney yang deficiency failing to warm the spleen, and is particularly well suited for the early morning diarrhea pattern where the stool is most loose in the early morning hours when kidney yang is at its lowest.
Mix the powder directly into food or grain at the dose recommended for your animal's species and body weight. Dogs and cats use the Canine Blend; horses use the Equine/Horse Blend. Dogs and cats receive the formula twice daily; horses receive two tablespoons twice daily for the first 20 days, then once daily for maintenance. If the horse initially refuses, start with a small amount mixed into grain and gradually increase until the horse is accustomed to the taste. Most horses will readily accept the herbs in their grain. Your authorizing veterinarian will confirm the appropriate dose and schedule for your individual animal.
Many pets show improvement in stool consistency and frequency within 2 to 4 weeks of consistent use as the spleen and kidney yang are warmed and the intestines' consolidating function is restored. Because the underlying spleen and kidney yang deficiency pattern is a chronic deficiency condition, a longer course of treatment of 8 to 12 weeks or more is typically needed to adequately warm the yang and maintain the improvement in digestive and intestinal function. Your veterinarian may recommend periodic reassessment to evaluate the pattern's response and adjust the treatment plan as the spleen and kidney yang are gradually restored.
Si Shen San is specifically indicated for the cold and yang deficiency pattern of chronic loose stool and diarrhea, where the stool is unformed or watery, worsens with cold, and is most pronounced in the early morning hours. It is not appropriate for diarrhea arising from damp-heat, food stagnation, liver overacting on the spleen, or acute infectious patterns, where warming and astringent herbs would be contraindicated or ineffective. Your authorizing veterinarian will determine which digestive support formula best matches your animal's full TCVM pattern diagnosis based on the character, timing, and accompanying signs of the loose stool presentation.
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