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Herbsmith Rx Shu Gan San is a classical Chinese herbal formula recommended by holistic veterinarians to dredge the liver, regulate qi, dispel stasis, invigorate the blood, and clear heat in dogs, cats, and horses. Comparable to Bupleurum and Evodia Combination, Comfort Liver Pills, Soothe Liver Pill, Liver Flow, and Bupleurum Liver Coursing Powder, it dredges the liver, regulates the qi, dispels stasis, relieves discomfort, invigorates the blood, and clears heat. A multifaceted formula addressing the combined pattern of liver qi stagnation with concurrent blood stasis and heat, well suited for pets and horses presenting with signs of liver qi stagnation complicated by blood stagnation and heat, including flank or abdominal sensitivity, irritability or emotional reactivity, a dull or stagnant coat, distension and discomfort that worsen with pressure, irregular heat signs alongside qi and blood stagnation signs, and the general signs of liver qi failing to move freely through the channels, organs, and blood vessels in an orderly and cool manner. Available as a concentrated powder mixed into food; cats and dogs use the Canine Blend, while horses use the Equine/Horse Blend. Dosing varies by species and body weight, and your authorizing veterinarian will provide specific guidance.
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For Dogs (Canine Blend Powder):
For Cats (Canine Blend Powder): ¼ tsp twice daily, or as prescribed
For Horses (Equine/Horse Blend, 1,000 lb horse): Two tablespoons twice daily for 20 days, then two tablespoons once daily in grain. If the horse initially refuses, start with a small amount mixed into grain and gradually increase until the horse is accustomed to the taste. Most horses will readily accept the herbs in their grain.
Active Ingredients: Huang Lian (Coptidis Rhizoma), Chai Hu (Bupleuri Radix), Dang Gui (Angelicae sinensis Radix), Qing Pi (Citri reticulatae viride Pericarpium), Tao Ren (Persicae Semen), Zhi Ke (Aurantii Fructus), Chuan Xiong (Chuanxiong Rhizoma), Bai Shao (Paeoniae Radix alba), Hong Hua (Carthami Flos)
Inactive Ingredient: Flaxseed
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Shu Gan San is a nine-herb formula addressing the combined pattern of liver qi stagnation, blood stasis, and heat through three coordinated groups of herbs: liver qi-dredging and heat-clearing herbs, blood-invigorating and stasis-resolving herbs, and liver blood-nourishing and liver-softening herbs:
Shu Gan San contains multiple blood-invigorating and stasis-resolving herbs, most significantly the classical Tao Ren and Hong Hua pair, as well as Dang Gui and Chuan Xiong, all of which have known antiplatelet and blood-moving properties that can have additive effects with pharmaceutical anticoagulant and antiplatelet medications. Pets currently on anticoagulant, antiplatelet, anti-inflammatory, or cardiovascular medications should use this formula only under veterinary supervision, as the combined blood-invigorating action of four herbs with blood-moving properties represents a meaningful interaction risk with blood-thinning pharmaceuticals, and herb-drug interaction research in dogs, cats, and horses remains limited. Huang Lian also has known effects on certain hepatic cytochrome P450 enzyme pathways that may affect the metabolism of hepatically processed pharmaceuticals.
Medication categories warranting extra caution include anticoagulant and antiplatelet medications, non-steroidal anti-inflammatory drugs, cardiovascular medications including cardiac glycosides and antiarrhythmics, hepatically metabolized pharmaceuticals where Huang Lian's enzyme effects may alter drug levels, and immunosuppressive or chemotherapy medications. Your authorizing veterinarian must assess the full medication list and the animal's condition and laboratory results before initiating this formula, given the number of blood-moving herbs it contains.
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In Traditional Chinese Veterinary Medicine, Shu Gan San is indicated for the combined pattern of liver qi stagnation with blood stasis and heat, presenting with flank or abdominal sensitivity, irritability or emotional reactivity, distension and discomfort that worsen with pressure, a dull or stagnant coat, heat signs alongside qi and blood stagnation signs, and the general signs of liver qi failing to move freely while blood stasis and heat have developed as secondary consequences of the chronic constraint. Comparable to Bupleurum and Evodia Combination, Comfort Liver Pills, Soothe Liver Pill, Liver Flow, and Bupleurum Liver Coursing Powder, it is indicated when liver qi stagnation has progressed beyond simple qi constraint to involve both the blood level and the generation of heat, requiring a formula that addresses all three aspects simultaneously.
Mix the powder directly into food or grain at the dose recommended for your animal's species and body weight. Dogs and cats use the Canine Blend; horses use the Equine/Horse Blend. Dogs and cats receive the formula twice daily; horses receive two tablespoons twice daily for the first 20 days, then once daily for maintenance. If the horse initially refuses, start with a small amount mixed into grain and gradually increase until the horse is accustomed to the taste. Most horses will readily accept the herbs in their grain. Your authorizing veterinarian will confirm the appropriate dose and schedule for your individual animal.
Many pets show improvement in comfort, coat quality, and emotional reactivity within 3 to 6 weeks of consistent use as the liver qi stagnation is dredged, the blood stasis is resolved, and the heat is cleared. Because the combined liver qi stagnation, blood stasis, and heat pattern addressed by Shu Gan San typically reflects a more established and layered pattern than simple qi stagnation alone, a course of treatment of 8 to 12 weeks or more is often needed to adequately address all three layers of the pattern and maintain improvement. Your veterinarian will assess both the qi stagnation and blood stasis components as the pattern evolves and may adjust the formula or dose as each layer responds to treatment.
Shu Gan San addresses a more complex, layered pattern than straightforward liver qi stagnation formulas, which typically use qi-moving and liver-dredging herbs without blood stasis-resolving and heat-clearing herbs. By including Tao Ren and Hong Hua for blood stasis, Huang Lian for heat clearance, and Dang Gui and Bai Shao for liver blood nourishment alongside the liver qi-dredging herbs Chai Hu, Qing Pi, and Zhi Ke, Shu Gan San addresses the full combined pattern of liver qi stagnation that has generated both heat and blood stagnation as secondary consequences of the chronic constraint. Your authorizing veterinarian will determine which liver qi stagnation formula is most appropriate for your animal's specific TCVM pattern based on whether blood stasis, heat, blood deficiency, or other concurrent patterns are present alongside the liver qi constraint.
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