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Recommended by holistic veterinarians, Herbsmith Rx Peony Calm Shen is a Traditional Chinese Veterinary Medicine (TCVM) herbal formula that calms the Heart Shen, nourishes the Heart, soothes Liver Qi Stagnation, and nourishes Blood in dogs and cats presenting with the combined pattern of anxiety, fear, irritability, and aggression. In TCVM, anxiety and fear are the negative emotional expressions of a disturbed Heart Shen - the Heart's spirit or consciousness - while irritability and aggression are the negative emotional expressions of Liver imbalance, specifically Liver Qi Stagnation. It is not unusual in veterinary practice to see these two patterns together, because in the TCVM Five Element framework, the Liver (Wood element) generates and promotes the Heart (Fire element): Wood promotes Fire. When Liver Qi Stagnation is present - brought on by chronic stress, frustration, environmental toxins, or constitutional factors - the stagnant Liver Qi exerts an excessive promoting influence on the Heart, over-stimulating the Heart Fire and disturbing the Heart Shen. The result is the clinically common combination of the fear and anxiety of disturbed Heart Shen occurring simultaneously with the irritability and aggression of Liver Qi Stagnation - the pattern of the fear-aggressive dog. Peony Calm Shen addresses this combined pattern with a sixteen-herb strategy that calms and nourishes Heart Shen, soothes and regulates Liver Qi, and nourishes the Heart Blood and Yin that sustain calm Shen over time. Available in powder for dogs and cats (75g, 150g, 500g, 900g, 1200g). Dosing varies by body weight; your authorizing veterinarian will provide specific guidance.
Precaution: Not to be used in pregnant pets.
VETERINARY AUTHORIZATION REQUIRED: Submit Your Authorization Request or Request a TCVM Telemedicine Consultation
Active ingredients: Bai Shao Yao (Paeonia lactiflora, white) - White Peony root; Bai Zi Ren (Platycladus orientalis, seed) - Biota seed (Arborvitae seed); Chai Hu (Bupleurum chinense) - Bupleurum root; Dan Shen (Salvia miltiorrhiza) - Salvia root (Red Sage root); Dang Gui Tou (Angelica sinensis, head) - Angelica root head (Tang Kuei); Fu Shen (Poria cocos, with pine root) - Poria with wood root (Heart-calming Poria); Mai Men Dong (Ophiopogon japonicus) - Ophiopogon tuber (Liriope); Mu Li Shu (Ostrea gigas, calcined) - Calcined Oyster shell; Qing Pi (Citrus reticulata, green peel) - Green Tangerine peel; Suan Zao Ren (Ziziphus spinosa, seed) - Sour Jujube seed (Zizyphus seed); Tian Men Dong (Asparagus cochinchinensis) - Asparagus tuber; Wu Wei Zi (Schisandra chinensis) - Schisandra fruit (Five Flavor berry); Xiang Fu Zi (Cyperus rotundus) - Cyperus rhizome (Nut Grass); Xuan Shen (Scrophularia ningpoensis) - Scrophularia root; Ye Jiao Teng (Polygonum multiflorum, vine) - Polygonum multiflorum vine (He Shou Wu vine); Yuan Zhi (Polygala tenuifolia) - Polygala root.
Inactive ingredients: Flaxseed (in all powder forms).
Not to be used in pregnant pets.
VETERINARY AUTHORIZATION REQUIRED: Submit Your Authorization Request or Request a TCVM Telemedicine Consultation
Peony Calm Shen is a sixteen-herb formula organized into four therapeutic layers: Heart Shen calming and anchoring, Heart Blood and Yin nourishment, Liver Qi soothing and regulation, and Shen consolidation and harmonization:
Herbsmith Rx Peony Calm Shen contains Dan Shen (Salvia miltiorrhiza), which has well-documented effects on hepatic drug metabolism (CYP enzyme pathways) and Blood-invigorating properties, Dang Gui Tou (Angelica sinensis) with mild Blood-nourishing and moving properties, and Chai Hu (Bupleurum), which has immune-modulating and hepatic properties. Do not use this formula in pregnant pets. Dogs and cats on prescription medications should use this formula under veterinary supervision.
Medication categories warranting extra caution include sedative or anxiolytic medications (concurrent use of TCVM Shen-calming herbs with pharmaceutical sedatives, benzodiazepines, or anxiolytics may potentiate sedative effects; coordination with your veterinarian is essential when combining this formula with pharmaceutical behavioral management medications), anticoagulant or antiplatelet medications (Dan Shen has significant interactions with warfarin and other anticoagulants documented in the literature; this is a high-priority drug interaction concern requiring veterinary monitoring), cardiac medications (Dan Shen may interact with digoxin and other cardiac glycosides), hepatic medications or drugs metabolized through CYP pathways (Dan Shen and Chai Hu both have documented hepatic effects), and animals on multiple concurrent prescription medications. Your veterinarian can determine appropriateness based on your pet's condition, current medications, and laboratory results.
Not to be used in pregnant pets.
VETERINARY AUTHORIZATION REQUIRED: Submit Your Authorization Request or Request a TCVM Telemedicine Consultation
Fear aggression in TCVM is the clinical expression of a combined Heart Shen and Liver Qi pattern: the fear and anxiety come from disturbed Heart Shen, while the irritability and aggression come from Liver Qi Stagnation. This pattern is particularly common and clinically important because of the Five Element Wood-promotes-Fire relationship between the Liver and Heart. When Liver Qi becomes stagnant - as it commonly does in today's animals under chronic stress, environmental pressure, and constitutional strain - the stagnant Liver Qi exerts an exaggerated promoting influence on the Heart through the Wood-Fire pathway, over-stimulating the Heart Fire and disturbing the Heart Shen. The result is the simultaneous presentation of Liver-driven irritability and aggression alongside Heart-driven fear and anxiety that characterizes fear aggression. Standard anxiety formulas that only calm the Heart Shen do not resolve the Liver Qi Stagnation root, and the Heart Shen disturbance tends to recur. Peony Calm Shen addresses both the Heart Shen branch and the Liver Qi Stagnation root simultaneously, making it the appropriate formula for the combined fear-aggressive pattern rather than anxiety or aggression alone.
Mix the powder directly into your pet's food twice daily. For dogs: under 15 lbs, give 1/4 teaspoon twice daily; 15-30 lbs, give 1/2 teaspoon twice daily; 31-80 lbs, give 1 teaspoon twice daily; 81-120 lbs, give 1-1/2 teaspoons twice daily; over 120 lbs, give 2 teaspoons twice daily. For cats: give 1/4 teaspoon twice daily. Administer as prescribed by your authorizing veterinarian, who may adjust dosing based on your pet's specific pattern and response. Do not use this formula in pregnant pets.
Because this formula addresses constitutional Heart Blood deficiency and Liver Qi Stagnation alongside the behavioral expressions of those patterns, meaningful improvement typically requires consistent twice-daily use over 4 to 8 weeks. Some animals with milder or more recently established patterns may show earlier signs of improved emotional regulation - reduced reactivity, greater ease of settling, and softened fear responses - within 2 to 4 weeks. Animals with long-standing, deeply established Liver Qi Stagnation and Heart Blood deficiency patterns may require longer sustained use, as restoring adequate Heart Blood and resolving chronic Liver Qi constraint is a gradual constitutional process. Because the underlying patterns (chronic stress, constitutional Liver Qi Stagnation, Heart Blood deficiency) are often persistent, ongoing long-term use is frequently appropriate for continued behavioral and emotional support. Your authorizing veterinarian can monitor your pet's response and adjust dosing or duration as needed.
This is an important safety question that requires veterinary supervision. Several of this formula's herbs - particularly Dan Shen (Salvia miltiorrhiza) and Chai Hu (Bupleurum) - have documented effects on hepatic drug-metabolizing enzyme pathways (CYP450 enzymes) that can affect the blood levels of pharmaceutical medications metabolized through those pathways. Additionally, the Shen-calming herbs in this formula may potentiate the sedative effects of pharmaceutical anxiolytics or sedatives. Dan Shen specifically has well-documented interactions with warfarin and cardiac glycosides. This does not mean the formula cannot be used alongside conventional behavioral management - many dogs and cats benefit from integrative TCVM and pharmaceutical approaches together - but concurrent use requires active veterinary oversight and medication monitoring, particularly during the initial combination period. Your authorizing veterinarian can determine the safest and most effective integrative protocol for your pet's specific medications and behavioral management plan.
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