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Herbsmith Rx Long Dan Xie Gan San is a classical Chinese herbal formula recommended by holistic veterinarians to drain excess fire from the liver and gallbladder, clear and drain damp-heat from the lower burner, and address liver and gallbladder repletion heat and damp-heat patterns in dogs, cats, and horses. Comparable to Gentiana Longdancao Decoction to Drain the Liver, Snake and Dragon, Quell Fire, Gentiana Drain the Liver Pills, Gentiana Drain Fire, and Gentiana Combination, it drains excess fire from the liver and gallbladder, clears and drains damp-heat from the lower burner, and addresses both liver and gallbladder repletion heat and liver and gallbladder damp-heat. One of the most powerful fire-draining and damp-heat-clearing formulas in the classical Chinese herbal repertoire, Long Dan Xie Gan San addresses two distinct but related presentations of liver-gallbladder excess: upward-flaring liver and gallbladder fire producing the heat signs in the head, eyes, ears, and upper body, and downward-pouring damp-heat producing the damp-heat signs in the lower burner, urogenital tract, and lower limbs. The formula uses three coordinated herb groups: a fire-draining group (Long Dan Cao, Huang Qin, Zhi Zi) that clears the liver-gallbladder fire at the pattern's root; a damp-heat-draining group (Mu Tong, Che Qian Zi, Ze Xie) that drains the damp-heat downward and out through urination; and an essential yin-and-blood-protecting group (Sheng Di Huang, Dang Gui) that prevents the formula's intensely draining action from injuring the liver yin and blood during the treatment course. Well suited for dogs, cats, and horses presenting with liver and gallbladder fire or damp-heat, characterized by irritability or agitation, redness or heat in the eyes or ears, headshaking, bitter taste or yellow coatings in the mouth, urogenital damp-heat signs including burning or frequent urination or abnormal discharge, a red tongue with a yellow or yellow greasy coating, and a wiry rapid or slippery rapid pulse reflecting the liver-gallbladder fire or damp-heat pattern. Available as a concentrated powder mixed into food; cats and dogs use the Canine Blend, while horses use the Equine/Horse Blend. Dosing varies by species and body weight, and your authorizing veterinarian will provide specific guidance.
VETERINARY AUTHORIZATION REQUIRED: Submit Your Authorization Request or Request a TCVM Telemedicine Consultation
For Dogs (Canine Blend Powder):
For Cats (Canine Blend Powder): ¼ tsp twice daily, or as prescribed
For Horses (Equine/Horse Blend, 1,000 lb horse): Two tablespoons twice daily for 20 days, then two tablespoons once daily in grain. If the horse initially refuses, start with a small amount mixed into grain and gradually increase until the horse is accustomed to the taste. Most horses will readily accept the herbs in their grain.
Active Ingredients: Long Dan Cao (Radix Gentianae Longdancao) 14.5%, Sheng Di Huang (Radix Rehmanniae Glutinosae) 14.5%, Ze Xie (Rhizoma Alismatis Orientalis) 14.5%, Chai Hu (Radix Bupleuri) 14.5%, Gan Cao (Radix Glycyrrhizae Uralensis) 7%, Che Qian Zi (Semen Plantaginis) 7%, Mu Tong (Caulis Mutong) 7%, Zhi Zi (Fructus Gardeniae Jasminoidis) 7%, Huang Qin (Radix Scutellariae) 7%, Dang Gui (Radix Angelicae Sinensis) 7%
Inactive Ingredient: Flaxseed
VETERINARY AUTHORIZATION REQUIRED: Submit Your Authorization Request or Request a TCVM Telemedicine Consultation
Long Dan Xie Gan San is a ten-herb formula addressing liver and gallbladder repletion fire and damp-heat through three coordinated herb groups: a fire-draining and heat-clearing group that addresses the excess at the root, a damp-heat-draining and urination-promoting group that guides the damp-heat out of the body, and a yin-and-blood-protecting group that prevents the formula's aggressive draining action from injuring the liver yin and blood during the treatment course:
Long Dan Xie Gan San is an intensely bitter-cold and draining formula indicated for excess fire and damp-heat patterns, and is not appropriate for deficiency patterns, cold patterns, or animals without clear liver-gallbladder fire or damp-heat signs; extended use in the absence of an active excess pattern may injure the spleen qi and middle jiao through the formula's sustained cold-draining action. Dang Gui has mild anticoagulant and blood-invigorating properties that warrant monitoring in animals on anticoagulant or antiplatelet medications. Mu Tong (Caulis Mutong), as listed in the manufacturer's ingredient specification, warrants awareness regarding the aristolochic acid concerns historically associated with certain Mu Tong species; the formula is used under veterinary authorization and supervision, which allows the authorizing veterinarian to review the specific ingredient sourcing and determine appropriateness for the individual animal, particularly in animals with any pre-existing renal concerns. The formula's multiple urination-promoting herbs (Mu Tong, Che Qian Zi, Ze Xie) may interact with diuretic medications and warrant monitoring for fluid balance in animals on diuretics. The formula is not appropriate for animals with spleen qi deficiency, cold patterns, or yin deficiency without active excess heat signs.
Medication categories warranting extra caution include anticoagulant and antiplatelet medications (Dang Gui's blood-invigorating properties), diuretic medications (the formula's multiple urination-promoting herbs), hepatic or renal medications requiring careful monitoring (given the formula's strong draining action and the Mu Tong ingredient), and immunosuppressive or anti-inflammatory medications (where the formula's fire-draining action may complement or interact with pharmaceutical treatments for inflammatory or immune-mediated conditions). Your authorizing veterinarian will determine appropriateness based on your animal's condition, current medications, TCVM pattern diagnosis, and renal and hepatic function assessment.
VETERINARY AUTHORIZATION REQUIRED: Submit Your Authorization Request or Request a TCVM Telemedicine Consultation
In Traditional Chinese Veterinary Medicine, Long Dan Xie Gan San is indicated for two related presentations of liver-gallbladder excess: (1) liver and gallbladder repletion fire, presenting with irritability or agitation, redness or heat in the eyes or ears, headshaking, bitter taste or yellow mouth coatings, a red tongue with a yellow coating, and a wiry rapid pulse; and (2) liver and gallbladder damp-heat pouring downward into the lower burner, presenting with burning or frequent urination, urogenital inflammation or abnormal discharge, scrotal or vulvar damp-heat signs, a red tongue with a yellow greasy coating, and a slippery rapid pulse. Both presentations share the liver-gallbladder channel as the root of the excess, and the formula addresses both simultaneously through its fire-draining and damp-heat-draining herb groups. It is indicated for excess patterns only and is not appropriate for deficiency, cold, or mixed deficiency-excess patterns without veterinary confirmation of the active excess diagnosis.
Mix the powder directly into food or grain at the dose recommended for your animal's species and body weight. Dogs and cats use the Canine Blend; horses use the Equine/Horse Blend. Dogs and cats receive the formula twice daily; horses receive two tablespoons twice daily for the first 20 days, then once daily for maintenance. If the horse initially refuses, start with a small amount mixed into grain and gradually increase until the horse is accustomed to the taste. Most horses will readily accept the herbs in their grain. Your authorizing veterinarian will confirm the appropriate dose, treatment duration, and monitoring plan for your individual animal given the formula's intensely draining composition, and will also assess renal and hepatic function as appropriate before beginning the treatment course.
Because Long Dan Xie Gan San addresses active liver-gallbladder excess fire and damp-heat rather than a constitutional deficiency, response to treatment is typically seen relatively quickly - often within 1 to 3 weeks of consistent use as the excess fire is progressively drained and the damp-heat is cleared from the lower burner. The formula is not intended for indefinite long-term use due to its intensely bitter-cold and draining character; it is used until the active excess pattern is resolved, as confirmed by improvement in the fire and damp-heat signs and normalization of the tongue and pulse findings. Your veterinarian will monitor tongue quality, pulse, urinary signs, behavioral heat signs, and the overall fire-and-damp-heat pattern's resolution throughout the treatment course to determine the appropriate point at which to discontinue or transition to a maintenance formula.
Long Dan Xie Gan San is specifically indicated for liver and gallbladder repletion fire and damp-heat - excess patterns with a red tongue, yellow or yellow greasy coating, and wiry rapid or slippery rapid pulse. It is not appropriate for liver qi stagnation without significant fire (where Xiao Yao San or Chai Hu Shu Gan San would be more appropriate), liver yin deficiency heat (where Zhi Bai Di Huang Wan would be more appropriate), or deficiency patterns where the bitter-cold draining herbs would further deplete the patient's constitutional resources. The formula's inclusion of Sheng Di Huang and Dang Gui to protect the yin and blood during the draining treatment is a critical safety feature that distinguishes it from simpler fire-draining formulas, but the yin-protecting herbs do not make it appropriate for deficiency-pattern presentations. Your authorizing veterinarian will confirm the correct TCVM excess pattern diagnosis before beginning the treatment course.
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