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Herbsmith Rx Jia Wei Si Wu San is a classical Chinese herbal formula recommended by holistic veterinarians to tonify the blood, dry dampness, and strengthen the limbs in dogs, cats, and horses. Comparable to Augmented Four Substance Powder, it builds on the classical Si Wu Tang (Four Substance Decoction) base of Dang Gui, Shu Di Huang, Bai Shao, and Chuan Xiong, adding nine herbs to expand the formula into a comprehensive blood and qi tonification with damp-heat clearance and a limb-strengthening strategy. A thirteen-herb formula addressing blood deficiency with damp-heat accumulation in the channels and limbs from four simultaneous therapeutic angles, Jia Wei Si Wu San tonifies the blood from the classical Si Wu Tang foundation, adds qi and yin tonification through Ren Shen, Mai Men Dong, and Wu Wei Zi to support the blood tonification (since qi generates blood and yin nourishes the blood), clears the damp-heat from the lower jiao and limb channels through the Huang Bai and Zhi Mu paired combination alongside Huang Lian and Cang Zhu, and strengthens the sinews, bones, and lower limbs through Du Zhong and Niu Xi's kidney and liver tonification. Well suited for dogs, cats, and horses presenting with blood and qi deficiency with damp-heat accumulation, characterized by limb weakness, heaviness, and stiffness from blood deficiency failing to nourish the sinews and limbs alongside damp-heat obstructing the channels, a pale or slightly red tongue with a greasy coating reflecting the combined blood deficiency and damp-heat, and a thin or slippery pulse. Available as a concentrated powder mixed into food; cats and dogs use the Canine Blend, while horses use the Equine/Horse Blend. Dosing varies by species and body weight, and your authorizing veterinarian will provide specific guidance.
VETERINARY AUTHORIZATION REQUIRED: Submit Your Authorization Request or Request a TCVM Telemedicine Consultation
For Dogs (Canine Blend Powder):
For Cats (Canine Blend Powder): ¼ tsp twice daily, or as prescribed
For Horses (Equine/Horse Blend, 1,000 lb horse): Two tablespoons twice daily for 20 days, then two tablespoons once daily in grain. If the horse initially refuses, start with a small amount mixed into grain and gradually increase until the horse is accustomed to the taste. Most horses will readily accept the herbs in their grain.
Active Ingredients: Dang Gui (Radix Angelicae Sinensis), Mai Men Dong (Tuber Ophiopogonis Japonici), Huang Bai (Cortex Phellodendri), Cang Zhu (Rhizoma Atractylodis), Shu Di Huang (Radix Rehmanniae Glutinosae Conquitae), Bai Shao (Radix Paeoniae Lactiflorae), Chuan Xiong (Radix Ligustici Chuanxiong), Du Zhong (Cortex Eucommiae Ulmoidis), Wu Wei Zi (Fructus Schisandrae Chinensis), Ren Shen (Radix Ginseng), Huang Lian (Rhizoma Coptidis), Zhi Mu (Radix Anemarrhenae Asphodeloidis), Niu Xi (Radix Achyranthis Bidentatae)
Inactive Ingredient: Flaxseed
VETERINARY AUTHORIZATION REQUIRED: Submit Your Authorization Request or Request a TCVM Telemedicine Consultation
Jia Wei Si Wu San is a thirteen-herb formula organized into four coordinated layers: the classical Si Wu Tang blood-tonifying base, a qi and yin support layer, a damp-heat clearance layer, and a limb-strengthening layer:
Jia Wei Si Wu San contains Ren Shen (ginseng root), which has significant interactions with warfarin (may reduce anticoagulant effect), monoamine oxidase inhibitors, stimulant medications, and immunosuppressive drugs through its immune-modulating and adaptogenic properties. Dang Gui has estrogenic properties that warrant monitoring in animals on hormonal medications and may potentiate anticoagulant medications. Chuan Xiong and Niu Xi have blood-invigorating properties that warrant monitoring in animals on anticoagulant or antiplatelet medications. Shu Di Huang may affect blood glucose levels and should be monitored in animals on antidiabetic medications or insulin. Huang Bai, Huang Lian, and Zhi Mu are bitter-cold herbs with antibiotic and anti-inflammatory properties that may interact with antibiotics, antifungals, and anti-inflammatory medications. Wu Wei Zi may affect the metabolism of medications processed by the cytochrome P450 enzyme system. The formula combines blood tonification with damp-heat clearance and is indicated specifically for the combined blood deficiency and damp-heat pattern confirmed by the authorizing veterinarian; it is not appropriate for animals with pure blood deficiency without damp-heat, or for animals with cold or yang-deficient patterns where the bitter-cold damp-heat-clearing herbs would be contraindicated.
Medication categories warranting extra caution include anticoagulant and antiplatelet medications (Dang Gui, Chuan Xiong, Niu Xi's blood-invigorating effects and Ren Shen's potential anticoagulant interaction), hormonal medications (Dang Gui's estrogenic properties), antidiabetic medications and insulin (Shu Di Huang's blood glucose effects), antibiotics and antifungals (Huang Bai, Huang Lian, Zhi Mu's antimicrobial properties), immunosuppressive medications (Ren Shen's immune-modulating properties), and medications metabolized by the cytochrome P450 system (Wu Wei Zi). Your authorizing veterinarian will determine appropriateness based on your animal's condition, current medications, and confirmation of the combined blood deficiency and damp-heat pattern through tongue, pulse, and limb assessment.
VETERINARY AUTHORIZATION REQUIRED: Submit Your Authorization Request or Request a TCVM Telemedicine Consultation
In Traditional Chinese Veterinary Medicine, Jia Wei Si Wu San is indicated for blood and qi deficiency with damp-heat accumulation in the channels and limbs, presenting with limb weakness, heaviness, and stiffness from blood deficiency failing to nourish the sinews and limbs alongside damp-heat obstructing the channels, a pale or slightly red tongue with a greasy coating reflecting the combined blood deficiency and damp-heat accumulation, and a thin or slippery pulse. The formula's three-part indication of tonifying the blood, drying dampness, and strengthening the limbs reflects the three concurrent pathological mechanisms that must be addressed simultaneously: the blood deficiency root, the damp-heat branch obstruction, and the specific lower limb and sinew weakness that develops when kidney and liver deficiency and damp-heat accumulation combine to deprive the limb channels of normal qi, blood, and constitutional nourishment.
Mix the powder directly into food or grain at the dose recommended for your animal's species and body weight. Dogs and cats use the Canine Blend; horses use the Equine/Horse Blend. Dogs and cats receive the formula twice daily; horses receive two tablespoons twice daily for the first 20 days, then once daily for maintenance. If the horse initially refuses, start with a small amount mixed into grain and gradually increase until the horse is accustomed to the taste. Most horses will readily accept the herbs in their grain. Because Jia Wei Si Wu San contains Ren Shen and multiple blood-invigorating and bitter-cold herbs, your authorizing veterinarian will review current medications for ginseng interactions, anticoagulant interactions, and cytochrome P450 system interactions, and confirm the combined blood deficiency and damp-heat pattern before beginning use.
Because Jia Wei Si Wu San addresses a combined blood deficiency and damp-heat pattern with structural limb weakness, the timeline reflects both the gradual nature of constitutional blood tonification and the more progressive clearing of the damp-heat obstruction. Initial improvement in limb heaviness and the damp-heat component is sometimes seen within 3 to 6 weeks as the damp-heat-clearing herbs (Huang Bai, Zhi Mu, Huang Lian, Cang Zhu) begin to clear the channel obstruction. Meaningful improvement in limb strength, sinew and bone integrity, and the constitutional blood deficiency pattern typically requires 2 to 3 months or more of sustained use as the blood and qi tonification is progressively established through the Si Wu Tang base and Ren Shen, Mai Men Dong, and Wu Wei Zi support. Your veterinarian will monitor tongue quality, pulse character, limb strength, and coat and tissue quality throughout the treatment course to confirm the blood deficiency pattern is resolving and the damp-heat is clearing.
The classical Si Wu Tang (Four Substance Decoction) addresses pure blood deficiency through the foundational four-herb combination of Dang Gui, Shu Di Huang, Bai Shao, and Chuan Xiong and is the most widely used blood-tonifying formula in Chinese medicine. Jia Wei Si Wu San retains the complete Si Wu Tang base and adds nine herbs across three additional layers to address the compound pattern of blood deficiency with damp-heat accumulation and limb weakness that Si Wu Tang alone cannot treat: the qi and yin support layer (Ren Shen, Mai Men Dong, Wu Wei Zi) ensures the blood tonification is constitutionally complete from the qi and yin side, the damp-heat clearance layer (Huang Bai, Zhi Mu, Huang Lian, Cang Zhu) removes the channel obstruction that Si Wu Tang's tonic herbs cannot penetrate, and the limb-strengthening layer (Du Zhong, Niu Xi) adds the kidney and liver tonification and downward-conducting action that directs the formula's combined tonic and clearing effects to the lower limbs. When the presenting pattern is pure blood deficiency without damp-heat or limb-specific weakness, Si Wu Tang may be more appropriate; your authorizing veterinarian will differentiate the pattern to determine the most appropriate formula.
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