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Herbsmith Rx Ji Sheng Shen Qi Wan is a classical Chinese herbal formula recommended by holistic veterinarians to warm and tonify the kidney yang, regulate water metabolism, and support the resolution of fluid accumulation and edema in dogs, cats, and horses. Also known as the Cyathula and Plantago Combination, this ten-herb formula is the augmented version of the classical Jin Gui Shen Qi Wan (Kidney Qi Pill from the Golden Cabinet), enhanced with Chuan Niu Xi (cyathula root) and Che Qian Zi (plantago seed) by the Song dynasty physician Yan Yonghe in his Ji Sheng Fang (Formulas for Saving Lives, 1253 CE) to specifically address the water accumulation and edema that develops when kidney yang vacuity impairs the kidney's water-transforming and qi-transforming functions. The formula's core architecture follows the classical principle of warming the yang within the yin foundation: the six-herb Liu Wei Di Huang Wan base (Shu Di Huang, Shan Zhu Yu, Shan Yao, Fu Ling, Mu Dan Pi, Ze Xie) provides the kidney yin, essence, and spleen scaffold from which the yang is gently warmed by Fu Zi (prepared aconite) and Rou Gui (cinnamon bark), while the two Ji Sheng additions (Chuan Niu Xi and Che Qian Zi) extend the formula's water-regulating and edema-relieving action beyond the base formula's capacity. Well suited for dogs, cats, and horses presenting with kidney yang vacuity with water accumulation, characterized by dependent edema of the lower limbs and abdomen, reduced urination with dilute or pale urine, cold extremities and intolerance of cold, lower back and hindlimb weakness and stiffness, reduced thirst despite fluid accumulation, a pale, moist, and swollen tongue with a white slippery coating reflecting the cold-damp and yang vacuity pattern, and a deep, weak, slow pulse in the kidney position. Available as a concentrated powder mixed into food; cats and dogs use the Canine Blend, while horses use the Equine/Horse Blend. Dosing varies by species and body weight, and your authorizing veterinarian will provide specific guidance.
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For Dogs (Canine Blend Powder):
For Cats (Canine Blend Powder): ¼ tsp twice daily, or as prescribed
For Horses (Equine/Horse Blend, 1,000 lb horse): Two tablespoons twice daily for 20 days, then two tablespoons once daily in grain. If the horse initially refuses, start with a small amount mixed into grain and gradually increase until the horse is accustomed to the taste. Most horses will readily accept the herbs in their grain.
Active Ingredients: Shu Di Huang (Radix Rehmanniae Praeparata), Shan Zhu Yu (Fructus Corni), Shan Yao (Rhizoma Dioscoreae), Fu Ling (Poria), Mu Dan Pi (Cortex Moutan), Ze Xie (Rhizoma Alismatis), Fu Zi (Radix Aconiti Lateralis Praeparata), Rou Gui (Cortex Cinnamomi), Chuan Niu Xi (Radix Cyathulae), Che Qian Zi (Semen Plantaginis)
Inactive Ingredient: Flaxseed
VETERINARY AUTHORIZATION REQUIRED: Submit Your Authorization Request or Request a TCVM Telemedicine Consultation
Ji Sheng Shen Qi Wan is a ten-herb formula built on the classical six-herb Liu Wei Di Huang Wan yin and essence foundation (Shu Di Huang, Shan Zhu Yu, Shan Yao, Fu Ling, Mu Dan Pi, Ze Xie), augmented with two kidney yang-warming herbs (Fu Zi, Rou Gui) from the Jin Gui Shen Qi Wan base and two Ji Sheng water-regulating additions (Chuan Niu Xi, Che Qian Zi):
Ji Sheng Shen Qi Wan contains Fu Zi (prepared aconite root), which requires careful medication review before use due to its cardioactive alkaloid content (aconitine and related compounds) that persists even after the processing that reduces raw aconite's toxicity. Fu Zi has significant additive cardioactive effects with digoxin, cardiac glycosides, antiarrhythmic medications (including Class I and Class III antiarrhythmics), beta-blockers, and calcium channel blockers, and is absolutely contraindicated in animals with cardiac arrhythmias, bradycardia, or heart block. Fu Zi and Rou Gui together have potent warming and yang-stimulating effects that warrant monitoring in animals with hyperthyroidism or on thyroid medications. Rou Gui has anticoagulant properties that warrant monitoring in animals on warfarin, heparin, aspirin, or other anticoagulant medications. Chuan Niu Xi has blood-invigorating and mild anticoagulant properties that compound Rou Gui's anticoagulant effects. Che Qian Zi and Ze Xie have diuretic properties that may potentiate pharmaceutical diuretics (furosemide, hydrochlorothiazide, spironolactone) and warrant monitoring for electrolyte imbalances, particularly in animals already on diuretic therapy for cardiac or renal conditions. The formula is not appropriate for kidney yin vacuity without yang vacuity, heat patterns, or presentations without confirmed kidney yang vacuity with water accumulation.
Medication categories warranting extra caution include cardiac medications and antiarrhythmics (Fu Zi's cardioactive alkaloids), digoxin and cardiac glycosides (Fu Zi's additive cardioactive effects, absolutely contraindicated with cardiac arrhythmias), thyroid medications (Fu Zi and Rou Gui's warming yang-stimulating effects), anticoagulant and antiplatelet medications (Rou Gui and Chuan Niu Xi's anticoagulant properties), and pharmaceutical diuretics (Che Qian Zi and Ze Xie's additive diuretic effects with potential electrolyte imbalance). Your authorizing veterinarian will determine appropriateness based on your animal's condition, cardiac and renal status, current medications, and confirmation of kidney yang vacuity with a water-accumulation pattern through tongue quality, pulse character, and clinical assessment of edema, urination, and thermal sensitivity.
VETERINARY AUTHORIZATION REQUIRED: Submit Your Authorization Request or Request a TCVM Telemedicine Consultation
In Traditional Chinese Veterinary Medicine, Ji Sheng Shen Qi Wan is indicated for kidney yang vacuity with water accumulation and edema, the specific pattern where kidney yang deficiency impairs the kidney's qi-transformation function and leads to fluid accumulation in the lower jiao and dependent edema of the lower limbs and abdomen. Presenting signs include dependent edema, reduced urination with pale, dilute urine, cold extremities and cold intolerance, lower back and hindlimb weakness and stiffness, reduced thirst despite fluid retention, a pale, moist, swollen tongue with a white, slippery coating, and a deep, weak, slow pulse in the kidney position. Your authorizing veterinarian will differentiate the kidney yang vacuity with water accumulation pattern from spleen qi vacuity edema (which lacks the cold and yang vacuity signs), liver qi stagnation with water accumulation (which presents with a wiry pulse and different tongue signs), cardiac edema, or other fluid accumulation patterns that require different therapeutic formulas or conventional medical management.
Mix the powder directly into food or grain at the dose recommended for your animal's species and body weight. Dogs and cats use the Canine Blend; horses use the Equine/Horse Blend. Dogs and cats receive the formula twice daily; horses receive two tablespoons twice daily for the first 20 days, then once daily for maintenance. If the horse initially refuses, start with a small amount mixed into grain and gradually increase until the horse is accustomed to the taste. Most horses will readily accept the herbs in their grain. Because Ji Sheng Shen Qi Wan contains Fu Zi (prepared aconite) with cardioactive alkaloids and Che Qian Zi and Ze Xie with diuretic properties, your authorizing veterinarian will perform a full cardiac and renal assessment, review all current medications for interactions, and confirm the kidney yang vacuity with a water accumulation pattern before beginning use.
For the water accumulation and edema component, you may see improvement in urination volume and reduced dependent edema relatively early in the treatment course, often within 2 to 4 weeks, as Che Qian Zi, Ze Xie, and Fu Ling's combined water-regulating action begins to clear the accumulated fluid. For the kidney yang vacuity root, meaningful improvement in cold intolerance, lower back and hindlimb strength, and energy requires longer sustained use, typically 2 to 4 months or more as the yang is progressively restored through the formula's comprehensive warming and tonification strategy. Your authorizing veterinarian will monitor tongue and pulse quality, edema severity, urination patterns, and thermal sensitivity throughout the treatment course to confirm the pattern is resolving and adjust the formula as the kidney yang is progressively restored.
Jin Gui Shen Qi Wan (Kidney Qi Pill from the Golden Cabinet, from Zhang Zhongjing's Han dynasty classic) is the eight-herb base formula addressing kidney yang vacuity in general, using the six-herb Liu Wei Di Huang Wan yin foundation plus Fu Zi and Rou Gui for yang warming. Ji Sheng Shen Qi Wan adds Chuan Niu Xi and Che Qian Zi to the Jin Gui base, shifting the formula's primary indication from general kidney yang vacuity to kidney yang vacuity with water accumulation and lower limb edema specifically. Che Qian Zi promotes urination and drains dampness from the bladder and lower jiao, directly addressing the fluid accumulation that the base formula's Ze Xie and Fu Ling cannot adequately clear on their own when edema is prominent. Chuan Niu Xi directs the formula's action downward to the lower limbs and resolves blood stasis in the fluid-obstructed lower limb channels. When kidney yang vacuity presents without prominent edema, Jin Gui Shen Qi Wan is typically preferred; when edema and fluid accumulation are prominent alongside kidney yang vacuity, Ji Sheng Shen Qi Wan's two additions make it the more targeted and clinically appropriate choice.
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