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Herbsmith Rx Chai Hu Shu Gan San is a classical Chinese herbal formula recommended by holistic veterinarians to spread liver qi, harmonize the liver and spleen, activate the blood, and address stagnation-related discomfort and rib-side tension that liver qi stagnation can cause in dogs, cats, and horses. Also known as Bupleurum and Cyperus Powder, Bupleurum Liver Soothing Pills, Bupleurum Shu Gan, and Bupleurum and Cyperus Combination, Chai Hu Shu Gan San is one of the most important classical Chinese formulas for the liver qi stagnation pattern, derived from the classical formula Si Ni San with the addition of Chuan Xiong, Chen Pi, and Xiang Fu to strengthen the qi-moving, blood-activating, and liver-coursing actions. The seven-herb formula addresses the liver qi stagnation pattern through three simultaneous therapeutic strategies: spreading the liver qi and releasing the constrained liver wood energy (Chai Hu, Xiang Fu, Zhi Ke, Chen Pi), activating the blood and harmonizing the liver to address the blood stagnation that liver qi stagnation generates over time (Chuan Xiong, Bai Shao), and harmonizing the liver and spleen while moderating the formula's moving herbs (Zhi Gan Cao). Well suited for dogs, cats, and horses presenting with the liver qi stagnation pattern, characterized by irritability, emotional tension, or behavioral changes reflecting the constrained liver qi; rib-side tension or flank sensitivity; digestive irregularities from liver-spleen disharmony; a wiry pulse reflecting liver qi constraint; and a normal or slightly dusky tongue. Available as a concentrated powder mixed into food; dogs and cats use the Canine Blend, while horses use the Equine/Horse Blend. Dosing varies by species and body weight, and your authorizing veterinarian will provide specific guidance.
VETERINARY AUTHORIZATION REQUIRED: Submit Your Authorization Request or Request a TCVM Telemedicine Consultation
If the horse initially refuses, start with a small amount mixed into grain and gradually increase, or as directed by your veterinarian. Most horses will readily accept the herbs in their grain.
Active Ingredients: Chai Hu (Radix Bupleuri) (25%), Bai Shao (Radix Paeoniae Lactiflorae) (19%), Xiang Fu (Rhizoma Cyperi Rotundi) (19%), Zhi Ke (Fructus Citri Aurantii) (19%), Chuan Xiong (Radix Ligustici Chuanxiong) (12%), Zhi Gan Cao (Honey-fried Radix Glycyrrhizae Uralensis) (6%), Chen Pi (Pericarpium Citri Reticulatae)
Inactive Ingredient: Flaxseed
VETERINARY AUTHORIZATION REQUIRED: Submit Your Authorization Request or Request a TCVM Telemedicine Consultation
Chai Hu Shu Gan San is a seven-herb formula organized around three therapeutic strategies: liver qi spreading and constraint releasing (Chai Hu, Xiang Fu, Zhi Ke, Chen Pi), blood activation and liver nourishment (Chuan Xiong, Bai Shao), and liver-spleen harmonization (Zhi Gan Cao):
Chai Hu Shu Gan San contains liver qi-moving herbs, including Chai Hu, blood-activating herbs such as Chuan Xiong, liver-nourishing Bai Shao, and honey-fried licorice root (Zhi Gan Cao), which warrant consideration when reviewing medications. Pets taking prescription medications should use this formula under veterinary supervision because herb-drug interaction research in dogs and cats is limited. Horses taking prescription medications should also have their veterinarian review the formula before use.
Medication categories warranting extra caution include medications processed by the liver, anticoagulant or antiplatelet medications, corticosteroids, and antihypertensive medications. Your authorizing veterinarian can determine appropriateness based on your animal's condition, current medications, and laboratory results, together with confirmation of the liver qi stagnation pattern through tongue, pulse, and behavioral and clinical assessment.
VETERINARY AUTHORIZATION REQUIRED: Submit Your Authorization Request or Request a TCVM Telemedicine Consultation
In Traditional Chinese Veterinary Medicine, Chai Hu Shu Gan San is indicated for the liver qi stagnation pattern with liver-spleen disharmony. The clinical presentation centers on irritability, emotional tension, or behavioral changes reflecting constrained liver wood energy; rib-side or flank sensitivity; digestive irregularities including bloating, borborygmus, or alternating loose and firm stools from liver-spleen disharmony; and a wiry pulse reflecting constrained liver qi. The formula is particularly well suited for animals whose liver qi stagnation has a clear behavioral or emotional component alongside the physical signs, and for cases where rib-side tension and digestive irregularity coexist as the primary presentation. Your authorizing veterinarian will confirm the liver qi stagnation pattern through tongue and pulse examination, along with behavioral and clinical assessment.
Mix the powder into food or grain. Dogs and cats use the Canine Blend. For dogs under 30 lbs, give ½ tsp twice daily, or as directed by your veterinarian. For dogs 30-80 lbs, give 1 tsp twice daily, or as directed by your veterinarian. For dogs 80-120 lbs, give 1½ tsp twice daily, or as directed by your veterinarian. For dogs over 120 lbs, give 2 tsp twice daily, or as directed by your veterinarian. For cats, give ¼ tsp twice daily, or as directed by your veterinarian.
Horses use the Equine/Horse Blend. For a 1,000 lb horse, give two tablespoons twice daily, or as directed by your veterinarian. Continue the initial schedule for 20 days, or as directed by your veterinarian. Then give two tablespoons once daily in grain, or as directed by your veterinarian. If the horse initially refuses, start with a small amount mixed into grain and gradually increase, or as directed by your veterinarian. Veterinary review of all current medications is important before use, particularly medications processed by the liver and anticoagulant medications.
Because it addresses qi stagnation rather than deep constitutional vacuity, Chai Hu Shu Gan San typically shows relatively early improvement in the most responsive signs. Early improvement in behavioral signs of liver qi constraint (reduced irritability, decreased tension, improved emotional ease) and rib-side sensitivity may appear within 1 to 3 weeks as the formula's liver-coursing and qi-moving herbs begin addressing the stagnation. Improvement in the wiry pulse quality and digestive normalization typically requires 3 to 6 weeks. Chronic liver qi stagnation with established liver-spleen disharmony may require 2 to 3 months of treatment, or as directed by your veterinarian, before the pattern is meaningfully resolved. Your authorizing veterinarian will monitor pulse quality, behavioral signs, and digestive function throughout the treatment course.
Chai Hu Shu Gan San is sometimes used alongside other formulas when the liver qi stagnation pattern coexists with additional patterns requiring treatment, but all formula combinations require veterinary authorization and supervision. Common clinical scenarios where combination is considered include liver qi stagnation with underlying liver blood vacuity (where a blood-nourishing formula may be added), liver qi stagnation with heat signs that the formula's mild cold-natured herbs cannot address alone, or liver-spleen disharmony with significant spleen qi vacuity requiring additional spleen support. Because the formula's qi-moving and blood-activating herbs can interact with each other and with other formulas' blood-moving herbs, a comprehensive veterinary review of all formulas and medications used together is required before initiating any combination.
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