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Herbsmith Rx Bupleurum Harmonize Stomach is a classical Chinese herbal formula recommended by holistic veterinarians to course the liver qi, harmonize the liver and spleen, nourish the liver blood, and support healthy digestive function in dogs, cats, and horses experiencing signs of liver overacting on the spleen and stomach. Also known as the veterinary adaptation of Xiao Yao San (Free and Easy Wanderer), this eight-herb formula is one of the most clinically established and widely used liver qi stagnation with spleen and stomach disharmony formulas in the Chinese herbal tradition, organized around three simultaneous strategies: coursing the liver qi and relieving stagnation (Chai Hu, Bo He), nourishing the liver blood and softening the liver (Dang Gui, Bai Shao), and strengthening the spleen and stomach to support the middle jiao that the liver stagnation is overacting upon (Bai Zhu, Fu Ling, Gan Jiang, Gan Cao). In Chinese veterinary medicine, the liver is responsible for the smooth and orderly flow of qi throughout the body, and when the liver qi becomes stagnant, it loses its smoothing and spreading function and begins to overact on the adjacent organ systems - particularly the spleen and stomach, which depend on the liver's smooth qi flow for their receiving, transforming, and descending functions. When the liver overacts on the spleen and stomach, the stomach's descending function is disrupted (leading to nausea, vomiting, and bile reflux as the stomach qi rebels upward) and the spleen's transforming function is weakened (leading to poor appetite, abdominal gurgling, and digestive irregularity). Animals with a constitutional propensity for liver qi stagnation - typically high-energy, high-arousal, athletic animals who are strongly reactive to their environment - are particularly susceptible to developing this pattern, which can also be triggered by toxins, anesthesia, prolonged stress, frustration, and certain pharmaceuticals. Continuous or sporadic vomiting, especially when bile is present, gurgling abdominal sounds, and poor or picky appetite are all characteristic signs of liver overacting on spleen and stomach from a TCVM perspective. Available as a concentrated powder mixed into food. Dosing varies by species and body weight, and your authorizing veterinarian will provide specific guidance.
VETERINARY AUTHORIZATION REQUIRED: Submit Your Authorization Request or Request a TCVM Telemedicine Consultation
For Dogs (Powder):
For Cats (Powder): ¼ tsp twice daily, or as prescribed
For Horses (Powder): Dosing provided by your authorizing veterinarian based on body weight and clinical assessment.
Active Ingredients: Chai Hu (Bupleurum), Dang Gui (Angelica Tang Kuei), Bai Shao (Peony Root), Bai Zhu (Atractylodes), Bo He (Mentha), Gan Jiang (Ginger Rhizome), Gan Cao (Licorice Root), Fu Ling (Poria)
Inactive Ingredient: Flaxseed
VETERINARY AUTHORIZATION REQUIRED: Submit Your Authorization Request or Request a TCVM Telemedicine Consultation
Bupleurum Harmonize Stomach is the veterinary adaptation of the classical Xiao Yao San (Free and Easy Wanderer), an eight-herb formula organized around three therapeutic strategies: liver qi coursing and stagnation relieving (Chai Hu, Bo He), liver blood and yin nourishing (Dang Gui, Bai Shao), and spleen and middle jiao strengthening and harmonizing (Bai Zhu, Fu Ling, Gan Jiang, Gan Cao):
Bupleurum Harmonize Stomach has a manageable drug interaction profile centered primarily on its two blood-nourishing herbs. Dang Gui's coumarin and ferulic acid content and Bai Shao's paeoniflorin content both have mild anticoagulant effects; animals on warfarin, heparin, aspirin, clopidogrel, or other anticoagulant or antiplatelet medications warrant veterinary review before initiating this formula. The combined anticoagulant contribution of Dang Gui and Bai Shao together is more significant than either herb alone. Chai Hu's mild saikosaponin content warrants monitoring in animals with pre-existing liver conditions at standard doses, and prolonged high-dose use without veterinary monitoring is not recommended. Gan Cao's glycyrrhizin content warrants monitoring in animals on corticosteroids (potential additive sodium retention and potassium loss) and antihypertensive medications. Gan Jiang's warming nature warrants monitoring in animals on anticoagulant medications, where ginger's mild platelet-affecting properties could add to the anticoagulant concern from Dang Gui and Bai Shao.
Medication categories warranting extra caution: anticoagulant and antiplatelet medications (Dang Gui and Bai Shao combined anticoagulant effects - primary concern), corticosteroids (Gan Cao glycyrrhizin effects), antihypertensive medications (Gan Cao fluid-retaining tendency), and hepatically metabolized medications in animals with pre-existing liver conditions (Chai Hu saikosaponin monitoring). Because vomiting in dogs and cats can indicate conditions requiring urgent veterinary attention, including obstruction, pancreatitis, toxin ingestion, and metabolic disease, veterinary diagnosis before initiating this formula is important. Your authorizing veterinarian will determine appropriateness based on your pet's condition, current medications, tongue quality, pulse character, and constitutional assessment.
VETERINARY AUTHORIZATION REQUIRED: Submit Your Authorization Request or Request a TCVM Telemedicine Consultation
In Traditional Chinese Veterinary Medicine, the liver overacting on the spleen and stomach pattern produces characteristic digestive signs that reflect the stomach's inability to descend and the spleen's inability to transform effectively. The most distinctive signs are vomiting - particularly when bile is present, as bile-containing vomit indicates stomach qi rebelliously ascending rather than descending - along with gurgling abdominal sounds reflecting the disrupted qi movement in the middle jiao, and a picky or poor appetite reflecting the spleen's weakened receiving and transforming function. These signs may be continuous or sporadic, often worsening with stress, environmental change, or frustration, which directly provokes the liver qi stagnation. The constitutional profile is also characteristic: dogs with this pattern are often high-energy, high-arousal, athletic, and reactive, and their constitution predisposes them to liver qi constraint. The tongue may show a slightly tense or tight body with a thin coating, and the pulse is characteristically wiry, reflecting the liver qi constraint. These signs distinguish the liver overacting pattern from simple spleen vacuity or stomach yin vacuity patterns.
Mix the powder into food or feed at the dose recommended for your pet's species and body weight. The Canine Blend (75 g, 150 g, 500 g) is used for dogs and cats; the Equine Blend (900 g, 1200 g) is used for horses with dosing provided by your authorizing veterinarian. Because this formula contains Dang Gui and Bai Shao with combined anticoagulant effects, veterinary review of all current medications is important before use in animals on anticoagulant or antiplatelet medications. Animals with pre-existing liver conditions should have Chai Hu use monitored by their veterinarian. Because vomiting can indicate conditions requiring immediate veterinary attention (obstruction, pancreatitis, toxin ingestion), veterinary assessment before starting this formula is essential to confirm liver qi overacting on the spleen and stomach as the underlying cause.
As a formula that addresses both acute liver qi stagnation (branch) and underlying liver blood insufficiency and spleen weakness (root), Bupleurum Harmonize Stomach works on two timeframes. The liver qi-coursing herbs (Chai Hu, Bo He) may provide relatively earlier improvement in the acute digestive signs, with some reduction in vomiting frequency, appetite improvement, and reduction in abdominal gurgling potentially seen within 2 to 4 weeks as the liver constraint is relieved and the stomach qi begins to descend more normally. The deeper liver blood-nourishing and spleen-strengthening strategy (Dang Gui, Bai Shao, Bai Zhu, Fu Ling) requires sustained treatment over 6 to 12 weeks to meaningfully address the constitutional blood insufficiency and spleen weakness that underlie the pattern and provide more lasting digestive stability. Long-term use under veterinary supervision is often appropriate for animals with a constitutional propensity for this pattern, particularly high-arousal dogs for whom liver qi stagnation is a recurring tendency. Your authorizing veterinarian will monitor tongue quality, pulse, and clinical signs throughout.
Yes, Bupleurum Harmonize Stomach is available in both a Canine Blend (75 g, 150 g, 500 g) for dogs and cats and an Equine Blend (900 g, 1200 g) for horses. The liver overacting on spleen and stomach pattern occurs in horses and companion animals, and Xiao Yao San is used in equine TCVM practice for horses presenting with the characteristic signs of liver qi stagnation affecting the digestive system. Equine dosing is determined by your authorizing veterinarian based on the horse's body weight, clinical presentation, tongue quality, and pulse character. Drug interaction considerations for horses are the same as for dogs and cats: the primary concern is the anticoagulant effects of Dang Gui and Bai Shao, along with Gan Cao's glycyrrhizin content in horses on corticosteroids. Your authorizing veterinarian will provide equine-specific dosing and monitoring guidance.
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