Herbsmith Rx Rehmannia Settle Anxiety Herbal Formula for Cats and Dogs

{"id":6869316042822,"title":"Herbsmith Rx Rehmannia Settle Anxiety Herbal Formula for Cats and Dogs","handle":"herbsmith-rx-rehmannia-settle-anxiety-herbal-formula-for-cats-and-dogs","description":"\u003cdiv style=\"text-align: right;\"\u003e\u003cimg src=\"https:\/\/cdn.shopify.com\/s\/files\/1\/0021\/2110\/5457\/files\/veterinary_authorizaton_required_for_tcvm_herbal_formulas_240x240.jpg?v=1787081808\" alt=\"Veterinary Authorization Required for TCVM Herbal Formulas - TCVM Pet Supply\" style=\"margin: 5px 5px 5px 5px; float: right;\"\u003e\u003c\/div\u003e\n\u003cp style=\"text-align: left;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003eHerbsmith Rx Rehmannia Settle Anxiety is a classical Chinese herbal formula recommended by holistic veterinarians to calm the spirit, nourish the heart and kidney yin, tonify the blood, and support balanced behavior in dogs and cats exhibiting nervousness, hyperactivity, and discontentment from environmentally induced stress. Rehmannia Settle Anxiety helps maintain contentment during separation, travel, and tension caused by changes in the pet's daily routine by addressing the underlying heart-kidney yin vacuity and blood insufficiency pattern that allows the shen to become unsettled. This formula is the veterinary adaptation of the classical Tian Wang Bu Xin Dan (Emperor of Heaven's Special Pill to Tonify the Heart), one of the most complete and clinically respected heart and kidney yin-nourishing shen-calming formulas in the Chinese herbal tradition. In Chinese medicine, the heart not only pumps blood but also houses the shen (spirit), helping it remain settled and content in the world. In a healthy dog or cat, the heart fire (yang) and the kidney water (yin) are in dynamic balance, with the kidney yin nourishing and anchoring the heart fire and the heart fire warming the kidney yang. Excessive emotional or physical stress and aging can diminish normal kidney yin, leading to an inability to anchor and control the heart shen; when the heart is not nourished by sufficient yin and blood, the shen loses its stable residence, and characteristic nervousness, hyperactivity, and discontentment emerge. Rehmannia Settle Anxiety addresses this pattern through three simultaneous strategies: nourishing the kidney and heart yin (Sheng Di Huang, Tian Men Dong, Mai Men Dong, Xuan Shen), tonifying the heart blood (Dang Gui, Dan Shen), and directly calming the shen (Suan Zao Ren, Bai Zi Ren, Yuan Zhi, Fu Ling) while supporting the qi and directing the formula's action through the heart channel (Ren Shen, Wu Wei Zi, Jie Geng). Well suited for dogs and cats presenting with the heart and kidney yin vacuity with blood insufficiency pattern, characterized by a red or pale-red tongue with little or no coating reflecting yin vacuity; nervousness, restlessness, or hyperactivity that worsens with stress or environmental change; occasional waking at night or difficulty settling; mild heat signs from yin vacuity; and a thin or thin-rapid pulse. Available as a concentrated powder mixed into food. Dosing varies by species and body weight, and your authorizing veterinarian will provide specific guidance.\u003c\/span\u003e\u003c\/p\u003e\n\u003cp style=\"text-align: left;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cstrong\u003eVETERINARY AUTHORIZATION REQUIRED: \u003ca href=\"https:\/\/tcvmpet.com\/pages\/get-an-authorization\" rel=\"noopener\" style=\"color: rgb(0, 0, 0);\" target=\"_blank\"\u003eSubmit Your Authorization Request\u003c\/a\u003e or \u003ca href=\"https:\/\/tcvmpet.com\/pages\/schedule-a-consultation\" rel=\"noopener\" style=\"color: rgb(0, 0, 0);\" target=\"_blank\"\u003eRequest a TCVM Telemedicine Consultation\u003c\/a\u003e\u003c\/strong\u003e\u003c\/span\u003e\u003c\/p\u003e\n\u003ch2 style=\"text-align: left;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003eWhat It Supports\u003c\/span\u003e\u003c\/h2\u003e\n\u003cul style=\"text-align: left;\"\u003e\n\u003cli style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cstrong\u003eKidney and heart yin nourishment through Sheng Di Huang as the chief herb:\u003c\/strong\u003e Nourishes the kidney and heart yin, cools the blood, and provides the foundational yin replenishment that enables the formula to restore the heart-kidney yin balance through Sheng Di Huang (raw rehmannia root, Raw Rehmannia Root). Sheng Di Huang's sweet, bitter, and cold nature enters the heart, liver, and kidney channels to nourish the yin and cool the blood heat that yin vacuity generates, addressing the root of the heart-kidney yin insufficiency that is allowing the shen to become unsettled. As the formula's chief herb, Sheng Di Huang provides the primary yin-nourishing and blood-cooling action that all the formula's shen-calming herbs depend upon for their sustained effectiveness. Large doses can cause loose stools in animals with weak spleen digestion; monitoring is warranted in animals with pre-existing digestive sensitivity.\u003c\/span\u003e\u003c\/li\u003e\n\u003cli style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cstrong\u003eLung and heart yin nourishment and shen settling through Tian Men Dong:\u003c\/strong\u003e Nourishes the lung and kidney yin, clears heat, and moistens dryness through Tian Men Dong (asparagus tuber, Asparagus Tuber). Tian Men Dong's sweet, bitter, and very cold nature enters the lung and kidney channels to nourish the yin from the lung-kidney axis and clear the vacuity heat that the yin insufficiency generates, supporting the kidney's ability to anchor the heart fire and providing the lung-kidney yin that the heart depends upon. Generally well tolerated at standard doses; its cold nature warrants caution in animals with spleen yang vacuity.\u003c\/span\u003e\u003c\/li\u003e\n\u003cli style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cstrong\u003eStomach and heart yin nourishment and shen calming through Mai Men Dong:\u003c\/strong\u003e Nourishes the stomach and heart yin, clears heat from the heart, and gently calms the shen through Mai Men Dong (Ophiopogon tuber, Ophiopogon Tuber). Mai Men Dong's sweet, slightly bitter, and slightly cold nature enters the heart, stomach, and lung channels to nourish the heart yin directly and clear the mild heat that heart yin insufficiency generates, addressing the heart yin depletion from the heart channel directly alongside Tian Men Dong's kidney-lung yin nourishment. Generally well tolerated at standard doses.\u003c\/span\u003e\u003c\/li\u003e\n\u003cli style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cstrong\u003eHeart blood tonification and liver blood nourishment through Dang Gui:\u003c\/strong\u003e Tonifies and nourishes the blood, activates blood circulation, and addresses the heart blood insufficiency that accompanies the yin vacuity pattern through Dang Gui (angelica tang kuei, Angelica Tang Kuei). Dang Gui's sweet, acrid, and warm nature enters the heart, liver, and spleen channels to tonify the heart blood that the shen requires for stable residence, ensuring the heart's blood-housing function supports the yin-nourishing herbs' shen-calming action. Coumarin and ferulic acid anticoagulant effects; monitoring warranted in animals on anticoagulant or antiplatelet medications.\u003c\/span\u003e\u003c\/li\u003e\n\u003cli style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cstrong\u003eLung qi astringing, essence securing, and shen calming through Wu Wei Zi:\u003c\/strong\u003e Astringes the lung qi, secures the essence, prevents the leakage of the heart qi and shen, and calms the shen through Wu Wei Zi (schisandra fruit, Schisandra Fruit). Wu Wei Zi's sour and warm nature enters the lung, heart, and kidney channels to astringe and consolidate the heart qi and shen that the yin vacuity is failing to anchor, preventing the shen from becoming further unsettled and supporting the calming action of the shen-settling herbs. Schisandrin modulates CYP3A4 and CYP2C9 enzymes; monitoring is warranted in animals on hepatically metabolized medications.\u003c\/span\u003e\u003c\/li\u003e\n\u003cli style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cstrong\u003eHeart shen calming and heart blood nourishing through Bai Zi Ren:\u003c\/strong\u003e Nourishes the heart blood, calms the shen, addresses the shen restlessness from heart blood insufficiency, and gently moistens the intestines through Bai Zi Ren (biota seed, Biota Seed). Bai Zi Ren's sweet, neutral nature enters the heart, kidney, and large intestine channels to nourish heart blood and directly calm the shen, providing one of the formula's three primary shen-calming seeds (with Suan Zao Ren and Yuan Zhi). Generally well tolerated at standard doses.\u003c\/span\u003e\u003c\/li\u003e\n\u003cli style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cstrong\u003eHeart and liver blood nourishing and shen calming through Suan Zao Ren:\u003c\/strong\u003e Nourishes the heart and liver blood, calms the shen, and addresses the shen restlessness from heart-liver blood insufficiency through Suan Zao Ren (jujube seed, Jujube Seed). Suan Zao Ren's sweet, sour, and neutral nature enters the heart, liver, and gallbladder channels to nourish the blood and calm the shen from the heart-liver axis, providing the formula's most direct shen-nourishing and shen-calming action through blood tonification. Spinosin and jujuboside content with mild sedative-like effects; generally well tolerated at standard doses. Monitoring warranted in animals on sedatives where combined calming effects could be excessive.\u003c\/span\u003e\u003c\/li\u003e\n\u003cli style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cstrong\u003eQi tonification and heart-kidney communication support through Ren Shen:\u003c\/strong\u003e Tonifies the yuan qi (original qi), strengthens the heart qi, and supports the qi basis that enables the heart to house and stabilize the shen through Ren Shen (ginseng). Ren Shen's sweet, slightly bitter, and slightly warm nature enters the spleen, lung, and heart channels to tonify qi at the constitutional level, providing the qi foundation the heart needs to house the shen effectively and supporting the spleen qi that generates the blood the heart-shen nourishing herbs depend on. Ginsenoside content; monitoring warranted in animals on anticoagulants, MAOIs, stimulants, and antidiabetic medications. Do not use with MAOIs.\u003c\/span\u003e\u003c\/li\u003e\n\u003cli style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cstrong\u003eKidney and heart yin nourishment and vacuity heat clearing through Xuan Shen:\u003c\/strong\u003e Nourishes the kidney yin, clears vacuity heat, cools the blood, and supports the kidney water's ability to control the heart fire through Xuan Shen (scrophularia, Scrophularia). Xuan Shen's sweet, bitter, salty, and cold nature enters the lung, stomach, and kidney channels to nourish the kidney yin and clear the vacuity heat that yin insufficiency generates, supporting the kidney water's upward communication with the heart fire and complementing Sheng Di Huang's chief yin-nourishing action. Generally well tolerated at standard doses.\u003c\/span\u003e\u003c\/li\u003e\n\u003cli style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cstrong\u003eHeart blood activating and shen calming through Dan Shen:\u003c\/strong\u003e Activates the heart blood, clears heat from the heart, calms the shen, and addresses the blood stasis that can accompany heart blood insufficiency through Dan Shen (salvia, Salvia). Dan Shen's bitter and slightly cold nature enters the heart and pericardium channels to activate heart blood and clear mild heat from the heart, ensuring heart blood remains free-flowing and the heart channel is clear for the shen-calming herbs to exert their effect. Tanshinone and salvianolic acid content with significant anticoagulant effects; monitoring warranted in animals on warfarin, heparin, aspirin, clopidogrel, or other anticoagulant or antiplatelet medications. Do not use without veterinary review in animals on anticoagulant therapy.\u003c\/span\u003e\u003c\/li\u003e\n\u003cli style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cstrong\u003eSpleen qi tonification and shen calming through Fu Ling:\u003c\/strong\u003e Tonifies the spleen qi, drains dampness, calms the shen, and supports the middle jiao's ability to generate the blood and qi the heart requires through Fu Ling (poria, Poria). Fu Ling's sweet, neutral nature enters the heart, spleen, and kidney channels to tonify spleen qi, drain dampness from the middle jiao, and calm the shen directly through the heart channel, providing both middle jiao support for the formula's yin-nourishing and blood-tonifying strategy and direct shen-calming action. Generally well tolerated.\u003c\/span\u003e\u003c\/li\u003e\n\u003cli style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cstrong\u003eHeart-kidney communication opening and phlegm resolving through Yuan Zhi:\u003c\/strong\u003e Opens the heart orifices, resolves phlegm misting the heart, and strengthens the communication between the heart and kidney through Yuan Zhi (polygala, Polygala). Yuan Zhi's bitter, acrid, and slightly warm nature enters the heart, lung, and kidney channels to open the heart orifices, resolve phlegm obstruction interfering with heart-shen communication, and strengthen the heart-kidney axis communication disrupted by the yin vacuity pattern. Yuan Zhi is a critical herb for ensuring the formula's yin-nourishing and shen-calming herbs can effectively reach and settle the heart shen. GI sensitivity at higher doses; monitoring warranted in animals with pre-existing gastric conditions.\u003c\/span\u003e\u003c\/li\u003e\n\u003cli style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cstrong\u003eFormula directing to the heart channel and Lung qi diffusing through Jie Geng:\u003c\/strong\u003e Directs the formula's herbs to the heart and upper jiao through its ascending and diffusing action, and opens the lung qi to support the lung's role in the heart-kidney communication through Jie Geng (platycodon, Platycodon). Jie Geng's bitter, acrid, and neutral nature enters the lung channel to diffuse the lung qi and act as a messenger herb that directs the formula's action upward toward the heart, ensuring the yin-nourishing and shen-calming herbs are delivered effectively to the heart channel and upper jiao. As a traditional envoy (shi) herb, Jie Geng's role is directional rather than directly therapeutic. Generally well tolerated at standard doses.\u003c\/span\u003e\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003ch2 style=\"text-align: left;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003eTCVM Principles\u003c\/span\u003e\u003c\/h2\u003e\n\u003cul style=\"text-align: left;\"\u003e\n\u003cli style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cstrong\u003ePrimary action - heart and kidney yin vacuity with blood insufficiency and unsettled shen through the combined strategy of kidney and heart yin nourishment (Sheng Di Huang, Tian Men Dong, Mai Men Dong, Xuan Shen), heart blood tonification and activation (Dang Gui, Dan Shen), shen calming through blood and yin nourishment (Suan Zao Ren, Bai Zi Ren), heart orifice opening and heart-kidney communication strengthening (Yuan Zhi), qi tonification (Ren Shen, Fu Ling), qi astringing (Wu Wei Zi), and formula directing (Jie Geng):\u003c\/strong\u003e Rehmannia Settle Anxiety addresses the heart-kidney yin vacuity with unsettled shen pattern through four simultaneous therapeutic strategies. The four yin-nourishing herbs address the root yin insufficiency from multiple angles: Sheng Di Huang nourishes the kidney and heart yin from the deep constitutional level; Tian Men Dong nourishes the lung-kidney yin and clears vacuity heat; Mai Men Dong nourishes the heart and stomach yin directly; Xuan Shen nourishes the kidney yin and clears vacuity heat from the blood level. The blood-tonifying and activating herbs ensure the heart blood is sufficient to house the shen: Dang Gui tonifies and nourishes the blood; Dan Shen activates the heart blood and clears heart heat. The shen-calming seeds and qi herbs directly settle the unsettled shen: Suan Zao Ren nourishes heart-liver blood and calms the shen; Bai Zi Ren nourishes heart blood and calms the shen; Yuan Zhi opens the heart orifices; Fu Ling calms the shen through the heart channel; Ren Shen tonifies the yuan qi. Wu Wei Zi astringes and consolidates; Jie Geng directs the formula to the upper jiao. Treatment Principles: nourish the kidney and heart yin, tonify the blood, calm the shen, and address heart-kidney yin vacuity with unsettled shen.\u003c\/span\u003e\u003c\/li\u003e\n\u003cli style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cstrong\u003eSecondary action - pattern differentiation from liver qi stagnation with shen disturbance (requiring liver coursing and qi moving rather than yin nourishing), heart fire blazing from excess (requiring heat clearing and fire draining rather than yin tonification), and phlegm misting the heart without underlying yin vacuity (requiring phlegm-resolving strategies without the deep yin-nourishing approach):\u003c\/strong\u003e Rehmannia Settle Anxiety is indicated specifically for the heart-kidney yin vacuity pattern with unsettled shen, not for liver qi stagnation with shen disturbance (tense muscles, wiry pulse, distending sensations - requiring liver coursing rather than yin tonification), heart fire blazing from excess (bright red tongue with thick yellow coating, rapid-full pulse - requiring heat-draining rather than yin-nourishing strategies), or phlegm-misting-the-heart patterns without yin vacuity (requiring phlegm resolution without the deep yin-nourishing approach). The red or pale-red tongue with little coating and the thin-rapid pulse are the critical differentiating signs confirming the yin vacuity origin of the shen disturbance. Your authorizing veterinarian will confirm the heart-kidney yin vacuity pattern through tongue and pulse examination and clinical assessment of behavioral signs.\u003c\/span\u003e\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003ch2 style=\"text-align: left;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003eAvailable Forms\u003c\/span\u003e\u003c\/h2\u003e\n\u003cul style=\"text-align: left;\"\u003e\n\u003cli style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cstrong\u003ePowder - Canine Blend (for dogs and cats):\u003c\/strong\u003e Available in 75 g, 150 g, 500 g, 900 g, and 1200 g sizes; mix into food at the recommended dose for your pet's weight. Both dogs and cats use this blend.\u003c\/span\u003e\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003ch2 style=\"text-align: left;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003eSuggested Use\u003c\/span\u003e\u003c\/h2\u003e\n\u003cp style=\"text-align: left;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cstrong\u003eFor Dogs (Powder):\u003c\/strong\u003e\u003c\/span\u003e\u003c\/p\u003e\n\u003cul style=\"text-align: left;\"\u003e\n\u003cli style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003eUnder 30 lbs: ½ tsp twice daily, or as prescribed\u003c\/span\u003e\u003c\/li\u003e\n\u003cli style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e30-80 lbs: 1 tsp twice daily, or as prescribed\u003c\/span\u003e\u003c\/li\u003e\n\u003cli style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e80-120 lbs: 1½ tsp twice daily, or as prescribed\u003c\/span\u003e\u003c\/li\u003e\n\u003cli style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003eOver 120 lbs: 2 tsp twice daily, or as prescribed\u003c\/span\u003e\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003cp style=\"text-align: left;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cstrong\u003eFor Cats (Powder):\u003c\/strong\u003e ¼ tsp twice daily, or as prescribed\u003c\/span\u003e\u003c\/p\u003e\n\u003ch2 style=\"text-align: left;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003eIngredients\u003c\/span\u003e\u003c\/h2\u003e\n\u003cp style=\"text-align: left;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cstrong\u003eActive Ingredients:\u003c\/strong\u003e Sheng Di Huang (Raw Rehmannia Root), Tian Men Dong (Asparagus Tuber), Mai Men Dong (Ophiopogon Tuber), Dang Gui (Angelica Tang Kuei), Wu Wei Zi (Schisandra Fruit), Bai Zi Ren (Biota Seed), Suan Zao Ren (Jujube Seed), Ren Shen (Ginseng), Xuan Shen (Scrophularia), Dan Shen (Salvia), Fu Ling (Poria), Yuan Zhi (Polygala), Jie Geng (Platycodon)\u003c\/span\u003e\u003c\/p\u003e\n\u003cp style=\"text-align: left;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cstrong\u003eInactive Ingredient:\u003c\/strong\u003e Flaxseed\u003c\/span\u003e\u003c\/p\u003e\n\u003cp style=\"text-align: left;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cstrong\u003eVETERINARY AUTHORIZATION REQUIRED: \u003ca href=\"https:\/\/tcvmpet.com\/pages\/get-an-authorization\" rel=\"noopener\" style=\"color: rgb(0, 0, 0);\" target=\"_blank\"\u003eSubmit Your Authorization Request\u003c\/a\u003e or \u003ca href=\"https:\/\/tcvmpet.com\/pages\/schedule-a-consultation\" rel=\"noopener\" style=\"color: rgb(0, 0, 0);\" target=\"_blank\"\u003eRequest a TCVM Telemedicine Consultation\u003c\/a\u003e\u003c\/strong\u003e\u003c\/span\u003e\u003c\/p\u003e\n\u003ch2 style=\"text-align: left;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003eActive Ingredient TCVM Actions\u003c\/span\u003e\u003c\/h2\u003e\n\u003cp style=\"text-align: left;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003eRehmannia Settle Anxiety is the veterinary adaptation of the classical Tian Wang Bu Xin Dan, a thirteen-herb formula organized around four therapeutic strategies: kidney and heart yin nourishment (Sheng Di Huang, Tian Men Dong, Mai Men Dong, Xuan Shen), heart blood tonification and activation (Dang Gui, Dan Shen), shen calming through multiple routes (Suan Zao Ren, Bai Zi Ren, Yuan Zhi, Fu Ling), and qi support with formula directing (Ren Shen, Wu Wei Zi, Jie Geng):\u003c\/span\u003e\u003c\/p\u003e\n\u003cul style=\"text-align: left;\"\u003e\n\u003cli style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cstrong\u003eSheng Di Huang (Raw Rehmannia Root) - Raw Rehmannia Root:\u003c\/strong\u003e Chief herb; nourishes kidney and heart yin, cools blood heat from yin vacuity. Large doses may cause loose stools in animals with digestive sensitivity.\u003c\/span\u003e\u003c\/li\u003e\n\u003cli style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cstrong\u003eTian Men Dong (Asparagus Tuber) - Asparagus Root \/ Chinese Asparagus Tuber:\u003c\/strong\u003e Nourishes lung and kidney yin and clears vacuity heat from the lung-kidney axis. Cold nature; caution in animals with spleen yang vacuity.\u003c\/span\u003e\u003c\/li\u003e\n\u003cli style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cstrong\u003eMai Men Dong (Ophiopogon Tuber) - Ophiopogon Root \/ Dwarf Lilyturf Tuber:\u003c\/strong\u003e Nourishes heart and stomach yin and clears mild heart heat; addresses heart yin depletion directly. Generally well tolerated.\u003c\/span\u003e\u003c\/li\u003e\n\u003cli style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cstrong\u003eDang Gui (Angelica Tang Kuei) - Dong Quai \/ Chinese Angelica Root:\u003c\/strong\u003e Tonifies and nourishes heart blood; provides the blood foundation for stable shen residence. Coumarin and ferulic acid anticoagulant effects; monitoring warranted with anticoagulant and antiplatelet medications.\u003c\/span\u003e\u003c\/li\u003e\n\u003cli style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cstrong\u003eWu Wei Zi (Schisandra Fruit) - Schisandra Fruit \/ Five Flavor Fruit:\u003c\/strong\u003e Astringes and consolidates the heart qi and shen; prevents further leakage of shen from yin vacuity. Schisandrin modulates CYP3A4 and CYP2C9 enzymes; monitoring is warranted with hepatically metabolized medications.\u003c\/span\u003e\u003c\/li\u003e\n\u003cli style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cstrong\u003eBai Zi Ren (Biota Seed) - Biota Seed \/ Arborvitae Seed:\u003c\/strong\u003e Nourishes heart blood and calms the shen; one of the formula's three primary shen-calming seeds. Generally well tolerated.\u003c\/span\u003e\u003c\/li\u003e\n\u003cli style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cstrong\u003eSuan Zao Ren (Jujube Seed) - Jujube Seed \/ Sour Date Seed:\u003c\/strong\u003e Nourishes heart and liver blood and calms the shen; most direct shen-nourishing and shen-calming action of the three seeds. Spinosin and jujuboside content with mild calming effects; monitoring warranted in animals on sedatives.\u003c\/span\u003e\u003c\/li\u003e\n\u003cli style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cstrong\u003eRen Shen (Ginseng) - Asian Ginseng Root \/ Korean Ginseng:\u003c\/strong\u003e Tonifies the yuan qi and strengthens the heart qi; provides the qi foundation for shen housing. Ginsenoside content; monitoring warranted with anticoagulants, MAOIs, stimulants, and antidiabetic medications. Do not use with MAOIs.\u003c\/span\u003e\u003c\/li\u003e\n\u003cli style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cstrong\u003eXuan Shen (Scrophularia) - Scrophularia Root \/ Figwort Root:\u003c\/strong\u003e Nourishes kidney yin and clears vacuity heat from the blood level; supports kidney water control of heart fire. Generally well tolerated.\u003c\/span\u003e\u003c\/li\u003e\n\u003cli style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cstrong\u003eDan Shen (Salvia) - Salvia Root \/ Red Sage Root \/ Chinese Sage Root:\u003c\/strong\u003e Activates heart blood, clears heart heat, and calms the shen through blood activation. Tanshinone and salvianolic acid have anticoagulant effects; monitor closely when using warfarin, heparin, aspirin, clopidogrel, or other anticoagulant or antiplatelet medications. Do not use without veterinary review in animals on anticoagulant therapy.\u003c\/span\u003e\u003c\/li\u003e\n\u003cli style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cstrong\u003eFu Ling (Poria) - Poria \/ Hoelen \/ China Root:\u003c\/strong\u003e Tonifies spleen qi, drains dampness, and calms the shen through the heart channel; supports middle jiao for blood generation. Generally well tolerated.\u003c\/span\u003e\u003c\/li\u003e\n\u003cli style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cstrong\u003eYuan Zhi (Polygala) - Polygala Root \/ Senega Snakeroot:\u003c\/strong\u003e Opens the heart orifices, resolves phlegm misting the heart, and strengthens heart-kidney axis communication. GI sensitivity at higher doses; monitoring warranted in animals with gastric conditions.\u003c\/span\u003e\u003c\/li\u003e\n\u003cli style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cstrong\u003eJie Geng (Platycodon) - Platycodon Root \/ Balloon Flower Root:\u003c\/strong\u003e Envoy herb; directs the formula to the heart and upper jiao through ascending and diffusing action. Generally well tolerated at standard doses.\u003c\/span\u003e\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003ch2 style=\"text-align: left;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003ePotential Drug Interactions\u003c\/span\u003e\u003c\/h2\u003e\n\u003cp style=\"text-align: left;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003eRehmannia Settle Anxiety has a significant drug interaction profile given its combination of blood-activating and yin-nourishing herbs. The primary anticoagulant concern is Dan Shen's tanshinone and salvianolic acid content, which can significantly potentiate the effects of warfarin and other anticoagulant and antiplatelet medications; animals on anticoagulant therapy require veterinary review before starting this formula. Dang Gui's coumarin and ferulic acid content adds to the anticoagulant concern, making the combined Dan Shen and Dang Gui presence particularly important to flag for animals on blood-thinning medications. Ren Shen's ginsenoside content warrants monitoring in animals on MAOIs (do not use concurrently), stimulants, antidiabetic medications (combined glucose-lowering effects), and anticoagulants. Wu Wei Zi's schisandrin content modulates hepatic CYP3A4 and CYP2C9 enzyme activity, warranting monitoring in animals on cyclosporine, tacrolimus, chemotherapy agents, anticonvulsants, and other hepatically metabolized medications. Suan Zao Ren's mild calming spinosin and jujuboside content warrants monitoring in animals on sedatives or anxiolytic medications where combined calming effects could be excessive.\u003c\/span\u003e\u003c\/p\u003e\n\u003cp style=\"text-align: left;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003eMedication categories warranting extra caution: anticoagulant and antiplatelet medications (Dan Shen and Dang Gui combined anticoagulant effects - primary concern), MAOIs (Ren Shen - do not use concurrently), antidiabetic medications (Ren Shen glucose-lowering effects), hepatically metabolized medications subject to CYP3A4 and CYP2C9 interaction (Wu Wei Zi schisandrin), and sedatives and anxiolytics (Suan Zao Ren mild calming effects). Because behavioral signs in dogs and cats can have multiple underlying causes, including pain, neurological conditions, and metabolic disease, veterinary assessment is important before attributing the presentation to the heart-kidney yin vacuity pattern. Your authorizing veterinarian will determine appropriateness based on your pet's condition, current medications, tongue quality, pulse character, and clinical assessment of the behavioral signs.\u003c\/span\u003e\u003c\/p\u003e\n\u003cp style=\"text-align: left;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cstrong\u003eVETERINARY AUTHORIZATION REQUIRED: \u003ca href=\"https:\/\/tcvmpet.com\/pages\/get-an-authorization\" rel=\"noopener\" style=\"color: rgb(0, 0, 0);\" target=\"_blank\"\u003eSubmit Your Authorization Request\u003c\/a\u003e or \u003ca href=\"https:\/\/tcvmpet.com\/pages\/schedule-a-consultation\" rel=\"noopener\" style=\"color: rgb(0, 0, 0);\" target=\"_blank\"\u003eRequest a TCVM Telemedicine Consultation\u003c\/a\u003e\u003c\/strong\u003e\u003c\/span\u003e\u003c\/p\u003e\n\u003ch2 style=\"text-align: left;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003eFrequently Asked Questions\u003c\/span\u003e\u003c\/h2\u003e\n\u003ch3 style=\"text-align: left;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003eWhat behavioral signs is Rehmannia Settle Anxiety used for in TCVM?\u003c\/span\u003e\u003c\/h3\u003e\n\u003cp style=\"text-align: left;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003eIn Traditional Chinese Veterinary Medicine, Rehmannia Settle Anxiety is indicated for the heart and kidney yin vacuity pattern with unsettled shen, which manifests behaviorally as nervousness, hyperactivity, and discontentment triggered by environmentally induced stress, including separation, travel, and changes in daily routine. The clinical presentation includes a red or pale-red tongue with little or no coating reflecting yin vacuity; behavioral restlessness and hyperactivity that worsen with stress or environmental change; occasional nighttime waking or difficulty settling from shen disturbance; mild heat signs from yin vacuity heat; and a thin or thin-rapid pulse. This formula is best suited for stress-sensitive animals whose behavioral responses stem from the heart-kidney yin vacuity pattern and is not appropriate for behavioral issues from liver qi stagnation (requiring qi-moving strategies), heart fire blazing from excess (requiring heat-draining strategies), or fear-based responses from different constitutional patterns. Veterinary tongue and pulse examination is important to confirm the heart-kidney yin vacuity pattern before initiating treatment.\u003c\/span\u003e\u003c\/p\u003e\n\u003ch3 style=\"text-align: left;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003eHow is Rehmannia Settle Anxiety administered to dogs and cats?\u003c\/span\u003e\u003c\/h3\u003e\n\u003cp style=\"text-align: left;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003eMix the powder into food at the dose recommended for your pet's species and body weight. All variants are the Canine Blend powder, which is used for both dogs and cats. Because Rehmannia Settle Anxiety contains Dan Shen with significant anticoagulant effects, Ren Shen with MAOI interaction potential, and Wu Wei Zi with hepatic CYP enzyme modulation, veterinary review of all current medications is important before use. In particular, animals on warfarin or other anticoagulant medications, animals on MAOIs, and animals on hepatically metabolized medications require veterinary assessment of interaction potential before initiating this formula. For animals already on sedatives or anxiolytic medications, inform your veterinarian so they can account for the combined calming effects of Suan Zao Ren.\u003c\/span\u003e\u003c\/p\u003e\n\u003ch3 style=\"text-align: left;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003eHow long does it take to see results with Rehmannia Settle Anxiety?\u003c\/span\u003e\u003c\/h3\u003e\n\u003cp style=\"text-align: left;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003eAs a formula addressing the deep heart and kidney yin level, Rehmannia Settle Anxiety requires sustained treatment before the full shen-calming effect is seen. Some improvement in the most responsive behavioral signs (slight reduction in reactivity to environmental stressors, mild improvement in settling ability) may be seen within 3 to 5 weeks as the formula's shen-calming seeds (Suan Zao Ren, Bai Zi Ren) and qi-astringing herb (Wu Wei Zi) begin to consolidate the shen. More sustained improvement in the underlying nervousness and hyperactivity pattern, reflecting meaningful replenishment of the heart-kidney yin and heart blood, typically requires 6 to 12 weeks of consistent use as the yin-nourishing herbs rebuild the constitutional yin reserves. In animals with chronic or severe heart-kidney yin vacuity, long-term maintenance use under veterinary supervision is often appropriate. Your authorizing veterinarian will monitor tongue quality, pulse character, and behavioral signs throughout.\u003c\/span\u003e\u003c\/p\u003e\n\u003ch3 style=\"text-align: left;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003eCan Rehmannia Settle Anxiety be used alongside other calming supplements?\u003c\/span\u003e\u003c\/h3\u003e\n\u003cp style=\"text-align: left;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003eCombining Rehmannia Settle Anxiety with other calming supplements or medications requires veterinary guidance because of the formula's significant drug interaction profile. The primary concern with combination use is the anticoagulant interaction risk from Dan Shen and Dang Gui when combined with other blood-thinning supplements (fish oil at high doses, vitamin E, nattokinase) or medications. Combining with sedative medications or anxiolytic drugs requires veterinary monitoring of combined calming effects given Suan Zao Ren's mild sedative-like activity. Combining with other adaptogenic supplements containing ginseng or similar ginsenoside-containing herbs requires review of Ren Shen's interaction profile. Within the TCVM framework, Rehmannia Settle Anxiety is specifically formulated for the heart-kidney yin vacuity pattern and works most effectively when the correct pattern has been confirmed; combining with formulas addressing different patterns (liver qi stagnation, heart fire) without veterinary guidance may not provide additional benefit and could create unbalanced therapeutic effects. Your authorizing veterinarian will provide guidance on appropriate combination strategies based on your pet's complete clinical picture.\u003c\/span\u003e\u003c\/p\u003e","published_at":"2022-04-05T19:55:12-05:00","created_at":"2022-03-25T12:22:58-05:00","vendor":"Herbsmith Rx","type":"Pet Vitamins \u0026 Supplements","tags":["Deficiency_Yin","Product_Type_Herb","Species_Cat","Species_Dog","Vendor_Herbsmith_Rx"],"price":6884,"price_min":6884,"price_max":22200,"available":true,"price_varies":true,"compare_at_price":null,"compare_at_price_min":0,"compare_at_price_max":0,"compare_at_price_varies":false,"variants":[{"id":39934800298054,"title":"Powder - Canine \/ 75g Powder","option1":"Powder - Canine","option2":"75g Powder","option3":null,"sku":"HRSC-75","requires_shipping":true,"taxable":true,"featured_image":{"id":29301590786118,"product_id":6869316042822,"position":2,"created_at":"2022-06-07T00:38:58-05:00","updated_at":"2022-06-07T00:38:59-05:00","alt":"Herbsmith Rx Rehmannia Settle Anxiety Herbal Formula for Cats and Dogs powder","width":960,"height":997,"src":"\/\/tcvmpet.com\/cdn\/shop\/products\/herbsmith3_969x997px_1b463359-5b3b-4b05-98bc-654777f09571.jpg?v=1654580339","variant_ids":[39934800298054]},"available":true,"name":"Herbsmith Rx Rehmannia Settle Anxiety Herbal Formula for Cats and Dogs - Powder - Canine \/ 75g Powder","public_title":"Powder - Canine \/ 75g Powder","options":["Powder - Canine","75g Powder"],"price":7000,"weight":75,"compare_at_price":null,"inventory_management":null,"barcode":"180001134001","featured_media":{"alt":"Herbsmith Rx Rehmannia Settle Anxiety Herbal Formula for Cats and Dogs powder","id":21577470378054,"position":2,"preview_image":{"aspect_ratio":0.963,"height":997,"width":960,"src":"\/\/tcvmpet.com\/cdn\/shop\/products\/herbsmith3_969x997px_1b463359-5b3b-4b05-98bc-654777f09571.jpg?v=1654580339"}},"requires_selling_plan":false,"selling_plan_allocations":[],"quantity_rule":{"min":1,"max":null,"increment":1}},{"id":39934800363590,"title":"Powder - Canine \/ 150g Powder","option1":"Powder - Canine","option2":"150g Powder","option3":null,"sku":"HRSC-150","requires_shipping":true,"taxable":true,"featured_image":null,"available":true,"name":"Herbsmith Rx Rehmannia Settle Anxiety Herbal Formula for Cats and Dogs - Powder - Canine \/ 150g Powder","public_title":"Powder - Canine \/ 150g Powder","options":["Powder - Canine","150g Powder"],"price":8400,"weight":150,"compare_at_price":null,"inventory_management":null,"barcode":"180001134018","requires_selling_plan":false,"selling_plan_allocations":[],"quantity_rule":{"min":1,"max":null,"increment":1}},{"id":39934800429126,"title":"Powder - Canine \/ 500g Powder","option1":"Powder - Canine","option2":"500g Powder","option3":null,"sku":"HRSC-500","requires_shipping":true,"taxable":true,"featured_image":null,"available":true,"name":"Herbsmith Rx Rehmannia Settle Anxiety Herbal Formula for Cats and Dogs - Powder - Canine \/ 500g Powder","public_title":"Powder - Canine \/ 500g Powder","options":["Powder - Canine","500g Powder"],"price":14200,"weight":500,"compare_at_price":null,"inventory_management":null,"barcode":"180001134025","requires_selling_plan":false,"selling_plan_allocations":[],"quantity_rule":{"min":1,"max":null,"increment":1}},{"id":39934800494662,"title":"Powder - Canine \/ 900g Powder","option1":"Powder - 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Tablets \/ 90 count Tablets (900 mg)","public_title":"Tablets \/ 90 count Tablets (900 mg)","options":["Tablets","90 count Tablets (900 mg)"],"price":6884,"weight":1,"compare_at_price":null,"inventory_management":null,"barcode":"180001134056","requires_selling_plan":false,"selling_plan_allocations":[],"quantity_rule":{"min":1,"max":null,"increment":1}},{"id":39934976000070,"title":"Tablets \/ 270 count Tablets (900 mg)","option1":"Tablets","option2":"270 count Tablets (900 mg)","option3":null,"sku":"HRSC-270T","requires_shipping":true,"taxable":true,"featured_image":null,"available":true,"name":"Herbsmith Rx Rehmannia Settle Anxiety Herbal Formula for Cats and Dogs - Tablets \/ 270 count Tablets (900 mg)","public_title":"Tablets \/ 270 count Tablets (900 mg)","options":["Tablets","270 count Tablets (900 mg)"],"price":10932,"weight":1,"compare_at_price":null,"inventory_management":null,"barcode":"180001134063","requires_selling_plan":false,"selling_plan_allocations":[],"quantity_rule":{"min":1,"max":null,"increment":1}}],"images":["\/\/tcvmpet.com\/cdn\/shop\/products\/RehmanniaSettleAnxiety.jpg?v=1648239040","\/\/tcvmpet.com\/cdn\/shop\/products\/herbsmith3_969x997px_1b463359-5b3b-4b05-98bc-654777f09571.jpg?v=1654580339"],"featured_image":"\/\/tcvmpet.com\/cdn\/shop\/products\/RehmanniaSettleAnxiety.jpg?v=1648239040","options":["Type","Size"],"media":[{"alt":"Herbsmith Rx Rehmannia Settle Anxiety Herbal Formula for Cats and Dogs","id":21380303880262,"position":1,"preview_image":{"aspect_ratio":0.928,"height":458,"width":425,"src":"\/\/tcvmpet.com\/cdn\/shop\/products\/RehmanniaSettleAnxiety.jpg?v=1648239040"},"aspect_ratio":0.928,"height":458,"media_type":"image","src":"\/\/tcvmpet.com\/cdn\/shop\/products\/RehmanniaSettleAnxiety.jpg?v=1648239040","width":425},{"alt":"Herbsmith Rx Rehmannia Settle Anxiety Herbal Formula for Cats and Dogs powder","id":21577470378054,"position":2,"preview_image":{"aspect_ratio":0.963,"height":997,"width":960,"src":"\/\/tcvmpet.com\/cdn\/shop\/products\/herbsmith3_969x997px_1b463359-5b3b-4b05-98bc-654777f09571.jpg?v=1654580339"},"aspect_ratio":0.963,"height":997,"media_type":"image","src":"\/\/tcvmpet.com\/cdn\/shop\/products\/herbsmith3_969x997px_1b463359-5b3b-4b05-98bc-654777f09571.jpg?v=1654580339","width":960}],"requires_selling_plan":false,"selling_plan_groups":[],"content":"\u003cdiv style=\"text-align: right;\"\u003e\u003cimg src=\"https:\/\/cdn.shopify.com\/s\/files\/1\/0021\/2110\/5457\/files\/veterinary_authorizaton_required_for_tcvm_herbal_formulas_240x240.jpg?v=1787081808\" alt=\"Veterinary Authorization Required for TCVM Herbal Formulas - TCVM Pet Supply\" style=\"margin: 5px 5px 5px 5px; float: right;\"\u003e\u003c\/div\u003e\n\u003cp style=\"text-align: left;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003eHerbsmith Rx Rehmannia Settle Anxiety is a classical Chinese herbal formula recommended by holistic veterinarians to calm the spirit, nourish the heart and kidney yin, tonify the blood, and support balanced behavior in dogs and cats exhibiting nervousness, hyperactivity, and discontentment from environmentally induced stress. Rehmannia Settle Anxiety helps maintain contentment during separation, travel, and tension caused by changes in the pet's daily routine by addressing the underlying heart-kidney yin vacuity and blood insufficiency pattern that allows the shen to become unsettled. This formula is the veterinary adaptation of the classical Tian Wang Bu Xin Dan (Emperor of Heaven's Special Pill to Tonify the Heart), one of the most complete and clinically respected heart and kidney yin-nourishing shen-calming formulas in the Chinese herbal tradition. In Chinese medicine, the heart not only pumps blood but also houses the shen (spirit), helping it remain settled and content in the world. In a healthy dog or cat, the heart fire (yang) and the kidney water (yin) are in dynamic balance, with the kidney yin nourishing and anchoring the heart fire and the heart fire warming the kidney yang. Excessive emotional or physical stress and aging can diminish normal kidney yin, leading to an inability to anchor and control the heart shen; when the heart is not nourished by sufficient yin and blood, the shen loses its stable residence, and characteristic nervousness, hyperactivity, and discontentment emerge. Rehmannia Settle Anxiety addresses this pattern through three simultaneous strategies: nourishing the kidney and heart yin (Sheng Di Huang, Tian Men Dong, Mai Men Dong, Xuan Shen), tonifying the heart blood (Dang Gui, Dan Shen), and directly calming the shen (Suan Zao Ren, Bai Zi Ren, Yuan Zhi, Fu Ling) while supporting the qi and directing the formula's action through the heart channel (Ren Shen, Wu Wei Zi, Jie Geng). Well suited for dogs and cats presenting with the heart and kidney yin vacuity with blood insufficiency pattern, characterized by a red or pale-red tongue with little or no coating reflecting yin vacuity; nervousness, restlessness, or hyperactivity that worsens with stress or environmental change; occasional waking at night or difficulty settling; mild heat signs from yin vacuity; and a thin or thin-rapid pulse. Available as a concentrated powder mixed into food. Dosing varies by species and body weight, and your authorizing veterinarian will provide specific guidance.\u003c\/span\u003e\u003c\/p\u003e\n\u003cp style=\"text-align: left;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cstrong\u003eVETERINARY AUTHORIZATION REQUIRED: \u003ca href=\"https:\/\/tcvmpet.com\/pages\/get-an-authorization\" rel=\"noopener\" style=\"color: rgb(0, 0, 0);\" target=\"_blank\"\u003eSubmit Your Authorization Request\u003c\/a\u003e or \u003ca href=\"https:\/\/tcvmpet.com\/pages\/schedule-a-consultation\" rel=\"noopener\" style=\"color: rgb(0, 0, 0);\" target=\"_blank\"\u003eRequest a TCVM Telemedicine Consultation\u003c\/a\u003e\u003c\/strong\u003e\u003c\/span\u003e\u003c\/p\u003e\n\u003ch2 style=\"text-align: left;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003eWhat It Supports\u003c\/span\u003e\u003c\/h2\u003e\n\u003cul style=\"text-align: left;\"\u003e\n\u003cli style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cstrong\u003eKidney and heart yin nourishment through Sheng Di Huang as the chief herb:\u003c\/strong\u003e Nourishes the kidney and heart yin, cools the blood, and provides the foundational yin replenishment that enables the formula to restore the heart-kidney yin balance through Sheng Di Huang (raw rehmannia root, Raw Rehmannia Root). Sheng Di Huang's sweet, bitter, and cold nature enters the heart, liver, and kidney channels to nourish the yin and cool the blood heat that yin vacuity generates, addressing the root of the heart-kidney yin insufficiency that is allowing the shen to become unsettled. As the formula's chief herb, Sheng Di Huang provides the primary yin-nourishing and blood-cooling action that all the formula's shen-calming herbs depend upon for their sustained effectiveness. Large doses can cause loose stools in animals with weak spleen digestion; monitoring is warranted in animals with pre-existing digestive sensitivity.\u003c\/span\u003e\u003c\/li\u003e\n\u003cli style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cstrong\u003eLung and heart yin nourishment and shen settling through Tian Men Dong:\u003c\/strong\u003e Nourishes the lung and kidney yin, clears heat, and moistens dryness through Tian Men Dong (asparagus tuber, Asparagus Tuber). Tian Men Dong's sweet, bitter, and very cold nature enters the lung and kidney channels to nourish the yin from the lung-kidney axis and clear the vacuity heat that the yin insufficiency generates, supporting the kidney's ability to anchor the heart fire and providing the lung-kidney yin that the heart depends upon. Generally well tolerated at standard doses; its cold nature warrants caution in animals with spleen yang vacuity.\u003c\/span\u003e\u003c\/li\u003e\n\u003cli style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cstrong\u003eStomach and heart yin nourishment and shen calming through Mai Men Dong:\u003c\/strong\u003e Nourishes the stomach and heart yin, clears heat from the heart, and gently calms the shen through Mai Men Dong (Ophiopogon tuber, Ophiopogon Tuber). Mai Men Dong's sweet, slightly bitter, and slightly cold nature enters the heart, stomach, and lung channels to nourish the heart yin directly and clear the mild heat that heart yin insufficiency generates, addressing the heart yin depletion from the heart channel directly alongside Tian Men Dong's kidney-lung yin nourishment. Generally well tolerated at standard doses.\u003c\/span\u003e\u003c\/li\u003e\n\u003cli style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cstrong\u003eHeart blood tonification and liver blood nourishment through Dang Gui:\u003c\/strong\u003e Tonifies and nourishes the blood, activates blood circulation, and addresses the heart blood insufficiency that accompanies the yin vacuity pattern through Dang Gui (angelica tang kuei, Angelica Tang Kuei). Dang Gui's sweet, acrid, and warm nature enters the heart, liver, and spleen channels to tonify the heart blood that the shen requires for stable residence, ensuring the heart's blood-housing function supports the yin-nourishing herbs' shen-calming action. Coumarin and ferulic acid anticoagulant effects; monitoring warranted in animals on anticoagulant or antiplatelet medications.\u003c\/span\u003e\u003c\/li\u003e\n\u003cli style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cstrong\u003eLung qi astringing, essence securing, and shen calming through Wu Wei Zi:\u003c\/strong\u003e Astringes the lung qi, secures the essence, prevents the leakage of the heart qi and shen, and calms the shen through Wu Wei Zi (schisandra fruit, Schisandra Fruit). Wu Wei Zi's sour and warm nature enters the lung, heart, and kidney channels to astringe and consolidate the heart qi and shen that the yin vacuity is failing to anchor, preventing the shen from becoming further unsettled and supporting the calming action of the shen-settling herbs. Schisandrin modulates CYP3A4 and CYP2C9 enzymes; monitoring is warranted in animals on hepatically metabolized medications.\u003c\/span\u003e\u003c\/li\u003e\n\u003cli style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cstrong\u003eHeart shen calming and heart blood nourishing through Bai Zi Ren:\u003c\/strong\u003e Nourishes the heart blood, calms the shen, addresses the shen restlessness from heart blood insufficiency, and gently moistens the intestines through Bai Zi Ren (biota seed, Biota Seed). Bai Zi Ren's sweet, neutral nature enters the heart, kidney, and large intestine channels to nourish heart blood and directly calm the shen, providing one of the formula's three primary shen-calming seeds (with Suan Zao Ren and Yuan Zhi). Generally well tolerated at standard doses.\u003c\/span\u003e\u003c\/li\u003e\n\u003cli style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cstrong\u003eHeart and liver blood nourishing and shen calming through Suan Zao Ren:\u003c\/strong\u003e Nourishes the heart and liver blood, calms the shen, and addresses the shen restlessness from heart-liver blood insufficiency through Suan Zao Ren (jujube seed, Jujube Seed). Suan Zao Ren's sweet, sour, and neutral nature enters the heart, liver, and gallbladder channels to nourish the blood and calm the shen from the heart-liver axis, providing the formula's most direct shen-nourishing and shen-calming action through blood tonification. Spinosin and jujuboside content with mild sedative-like effects; generally well tolerated at standard doses. Monitoring warranted in animals on sedatives where combined calming effects could be excessive.\u003c\/span\u003e\u003c\/li\u003e\n\u003cli style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cstrong\u003eQi tonification and heart-kidney communication support through Ren Shen:\u003c\/strong\u003e Tonifies the yuan qi (original qi), strengthens the heart qi, and supports the qi basis that enables the heart to house and stabilize the shen through Ren Shen (ginseng). Ren Shen's sweet, slightly bitter, and slightly warm nature enters the spleen, lung, and heart channels to tonify qi at the constitutional level, providing the qi foundation the heart needs to house the shen effectively and supporting the spleen qi that generates the blood the heart-shen nourishing herbs depend on. Ginsenoside content; monitoring warranted in animals on anticoagulants, MAOIs, stimulants, and antidiabetic medications. Do not use with MAOIs.\u003c\/span\u003e\u003c\/li\u003e\n\u003cli style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cstrong\u003eKidney and heart yin nourishment and vacuity heat clearing through Xuan Shen:\u003c\/strong\u003e Nourishes the kidney yin, clears vacuity heat, cools the blood, and supports the kidney water's ability to control the heart fire through Xuan Shen (scrophularia, Scrophularia). Xuan Shen's sweet, bitter, salty, and cold nature enters the lung, stomach, and kidney channels to nourish the kidney yin and clear the vacuity heat that yin insufficiency generates, supporting the kidney water's upward communication with the heart fire and complementing Sheng Di Huang's chief yin-nourishing action. Generally well tolerated at standard doses.\u003c\/span\u003e\u003c\/li\u003e\n\u003cli style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cstrong\u003eHeart blood activating and shen calming through Dan Shen:\u003c\/strong\u003e Activates the heart blood, clears heat from the heart, calms the shen, and addresses the blood stasis that can accompany heart blood insufficiency through Dan Shen (salvia, Salvia). Dan Shen's bitter and slightly cold nature enters the heart and pericardium channels to activate heart blood and clear mild heat from the heart, ensuring heart blood remains free-flowing and the heart channel is clear for the shen-calming herbs to exert their effect. Tanshinone and salvianolic acid content with significant anticoagulant effects; monitoring warranted in animals on warfarin, heparin, aspirin, clopidogrel, or other anticoagulant or antiplatelet medications. Do not use without veterinary review in animals on anticoagulant therapy.\u003c\/span\u003e\u003c\/li\u003e\n\u003cli style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cstrong\u003eSpleen qi tonification and shen calming through Fu Ling:\u003c\/strong\u003e Tonifies the spleen qi, drains dampness, calms the shen, and supports the middle jiao's ability to generate the blood and qi the heart requires through Fu Ling (poria, Poria). Fu Ling's sweet, neutral nature enters the heart, spleen, and kidney channels to tonify spleen qi, drain dampness from the middle jiao, and calm the shen directly through the heart channel, providing both middle jiao support for the formula's yin-nourishing and blood-tonifying strategy and direct shen-calming action. Generally well tolerated.\u003c\/span\u003e\u003c\/li\u003e\n\u003cli style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cstrong\u003eHeart-kidney communication opening and phlegm resolving through Yuan Zhi:\u003c\/strong\u003e Opens the heart orifices, resolves phlegm misting the heart, and strengthens the communication between the heart and kidney through Yuan Zhi (polygala, Polygala). Yuan Zhi's bitter, acrid, and slightly warm nature enters the heart, lung, and kidney channels to open the heart orifices, resolve phlegm obstruction interfering with heart-shen communication, and strengthen the heart-kidney axis communication disrupted by the yin vacuity pattern. Yuan Zhi is a critical herb for ensuring the formula's yin-nourishing and shen-calming herbs can effectively reach and settle the heart shen. GI sensitivity at higher doses; monitoring warranted in animals with pre-existing gastric conditions.\u003c\/span\u003e\u003c\/li\u003e\n\u003cli style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cstrong\u003eFormula directing to the heart channel and Lung qi diffusing through Jie Geng:\u003c\/strong\u003e Directs the formula's herbs to the heart and upper jiao through its ascending and diffusing action, and opens the lung qi to support the lung's role in the heart-kidney communication through Jie Geng (platycodon, Platycodon). Jie Geng's bitter, acrid, and neutral nature enters the lung channel to diffuse the lung qi and act as a messenger herb that directs the formula's action upward toward the heart, ensuring the yin-nourishing and shen-calming herbs are delivered effectively to the heart channel and upper jiao. As a traditional envoy (shi) herb, Jie Geng's role is directional rather than directly therapeutic. Generally well tolerated at standard doses.\u003c\/span\u003e\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003ch2 style=\"text-align: left;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003eTCVM Principles\u003c\/span\u003e\u003c\/h2\u003e\n\u003cul style=\"text-align: left;\"\u003e\n\u003cli style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cstrong\u003ePrimary action - heart and kidney yin vacuity with blood insufficiency and unsettled shen through the combined strategy of kidney and heart yin nourishment (Sheng Di Huang, Tian Men Dong, Mai Men Dong, Xuan Shen), heart blood tonification and activation (Dang Gui, Dan Shen), shen calming through blood and yin nourishment (Suan Zao Ren, Bai Zi Ren), heart orifice opening and heart-kidney communication strengthening (Yuan Zhi), qi tonification (Ren Shen, Fu Ling), qi astringing (Wu Wei Zi), and formula directing (Jie Geng):\u003c\/strong\u003e Rehmannia Settle Anxiety addresses the heart-kidney yin vacuity with unsettled shen pattern through four simultaneous therapeutic strategies. The four yin-nourishing herbs address the root yin insufficiency from multiple angles: Sheng Di Huang nourishes the kidney and heart yin from the deep constitutional level; Tian Men Dong nourishes the lung-kidney yin and clears vacuity heat; Mai Men Dong nourishes the heart and stomach yin directly; Xuan Shen nourishes the kidney yin and clears vacuity heat from the blood level. The blood-tonifying and activating herbs ensure the heart blood is sufficient to house the shen: Dang Gui tonifies and nourishes the blood; Dan Shen activates the heart blood and clears heart heat. The shen-calming seeds and qi herbs directly settle the unsettled shen: Suan Zao Ren nourishes heart-liver blood and calms the shen; Bai Zi Ren nourishes heart blood and calms the shen; Yuan Zhi opens the heart orifices; Fu Ling calms the shen through the heart channel; Ren Shen tonifies the yuan qi. Wu Wei Zi astringes and consolidates; Jie Geng directs the formula to the upper jiao. Treatment Principles: nourish the kidney and heart yin, tonify the blood, calm the shen, and address heart-kidney yin vacuity with unsettled shen.\u003c\/span\u003e\u003c\/li\u003e\n\u003cli style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cstrong\u003eSecondary action - pattern differentiation from liver qi stagnation with shen disturbance (requiring liver coursing and qi moving rather than yin nourishing), heart fire blazing from excess (requiring heat clearing and fire draining rather than yin tonification), and phlegm misting the heart without underlying yin vacuity (requiring phlegm-resolving strategies without the deep yin-nourishing approach):\u003c\/strong\u003e Rehmannia Settle Anxiety is indicated specifically for the heart-kidney yin vacuity pattern with unsettled shen, not for liver qi stagnation with shen disturbance (tense muscles, wiry pulse, distending sensations - requiring liver coursing rather than yin tonification), heart fire blazing from excess (bright red tongue with thick yellow coating, rapid-full pulse - requiring heat-draining rather than yin-nourishing strategies), or phlegm-misting-the-heart patterns without yin vacuity (requiring phlegm resolution without the deep yin-nourishing approach). The red or pale-red tongue with little coating and the thin-rapid pulse are the critical differentiating signs confirming the yin vacuity origin of the shen disturbance. Your authorizing veterinarian will confirm the heart-kidney yin vacuity pattern through tongue and pulse examination and clinical assessment of behavioral signs.\u003c\/span\u003e\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003ch2 style=\"text-align: left;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003eAvailable Forms\u003c\/span\u003e\u003c\/h2\u003e\n\u003cul style=\"text-align: left;\"\u003e\n\u003cli style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cstrong\u003ePowder - Canine Blend (for dogs and cats):\u003c\/strong\u003e Available in 75 g, 150 g, 500 g, 900 g, and 1200 g sizes; mix into food at the recommended dose for your pet's weight. Both dogs and cats use this blend.\u003c\/span\u003e\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003ch2 style=\"text-align: left;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003eSuggested Use\u003c\/span\u003e\u003c\/h2\u003e\n\u003cp style=\"text-align: left;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cstrong\u003eFor Dogs (Powder):\u003c\/strong\u003e\u003c\/span\u003e\u003c\/p\u003e\n\u003cul style=\"text-align: left;\"\u003e\n\u003cli style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003eUnder 30 lbs: ½ tsp twice daily, or as prescribed\u003c\/span\u003e\u003c\/li\u003e\n\u003cli style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e30-80 lbs: 1 tsp twice daily, or as prescribed\u003c\/span\u003e\u003c\/li\u003e\n\u003cli style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e80-120 lbs: 1½ tsp twice daily, or as prescribed\u003c\/span\u003e\u003c\/li\u003e\n\u003cli style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003eOver 120 lbs: 2 tsp twice daily, or as prescribed\u003c\/span\u003e\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003cp style=\"text-align: left;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cstrong\u003eFor Cats (Powder):\u003c\/strong\u003e ¼ tsp twice daily, or as prescribed\u003c\/span\u003e\u003c\/p\u003e\n\u003ch2 style=\"text-align: left;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003eIngredients\u003c\/span\u003e\u003c\/h2\u003e\n\u003cp style=\"text-align: left;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cstrong\u003eActive Ingredients:\u003c\/strong\u003e Sheng Di Huang (Raw Rehmannia Root), Tian Men Dong (Asparagus Tuber), Mai Men Dong (Ophiopogon Tuber), Dang Gui (Angelica Tang Kuei), Wu Wei Zi (Schisandra Fruit), Bai Zi Ren (Biota Seed), Suan Zao Ren (Jujube Seed), Ren Shen (Ginseng), Xuan Shen (Scrophularia), Dan Shen (Salvia), Fu Ling (Poria), Yuan Zhi (Polygala), Jie Geng (Platycodon)\u003c\/span\u003e\u003c\/p\u003e\n\u003cp style=\"text-align: left;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cstrong\u003eInactive Ingredient:\u003c\/strong\u003e Flaxseed\u003c\/span\u003e\u003c\/p\u003e\n\u003cp style=\"text-align: left;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cstrong\u003eVETERINARY AUTHORIZATION REQUIRED: \u003ca href=\"https:\/\/tcvmpet.com\/pages\/get-an-authorization\" rel=\"noopener\" style=\"color: rgb(0, 0, 0);\" target=\"_blank\"\u003eSubmit Your Authorization Request\u003c\/a\u003e or \u003ca href=\"https:\/\/tcvmpet.com\/pages\/schedule-a-consultation\" rel=\"noopener\" style=\"color: rgb(0, 0, 0);\" target=\"_blank\"\u003eRequest a TCVM Telemedicine Consultation\u003c\/a\u003e\u003c\/strong\u003e\u003c\/span\u003e\u003c\/p\u003e\n\u003ch2 style=\"text-align: left;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003eActive Ingredient TCVM Actions\u003c\/span\u003e\u003c\/h2\u003e\n\u003cp style=\"text-align: left;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003eRehmannia Settle Anxiety is the veterinary adaptation of the classical Tian Wang Bu Xin Dan, a thirteen-herb formula organized around four therapeutic strategies: kidney and heart yin nourishment (Sheng Di Huang, Tian Men Dong, Mai Men Dong, Xuan Shen), heart blood tonification and activation (Dang Gui, Dan Shen), shen calming through multiple routes (Suan Zao Ren, Bai Zi Ren, Yuan Zhi, Fu Ling), and qi support with formula directing (Ren Shen, Wu Wei Zi, Jie Geng):\u003c\/span\u003e\u003c\/p\u003e\n\u003cul style=\"text-align: left;\"\u003e\n\u003cli style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cstrong\u003eSheng Di Huang (Raw Rehmannia Root) - Raw Rehmannia Root:\u003c\/strong\u003e Chief herb; nourishes kidney and heart yin, cools blood heat from yin vacuity. Large doses may cause loose stools in animals with digestive sensitivity.\u003c\/span\u003e\u003c\/li\u003e\n\u003cli style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cstrong\u003eTian Men Dong (Asparagus Tuber) - Asparagus Root \/ Chinese Asparagus Tuber:\u003c\/strong\u003e Nourishes lung and kidney yin and clears vacuity heat from the lung-kidney axis. Cold nature; caution in animals with spleen yang vacuity.\u003c\/span\u003e\u003c\/li\u003e\n\u003cli style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cstrong\u003eMai Men Dong (Ophiopogon Tuber) - Ophiopogon Root \/ Dwarf Lilyturf Tuber:\u003c\/strong\u003e Nourishes heart and stomach yin and clears mild heart heat; addresses heart yin depletion directly. Generally well tolerated.\u003c\/span\u003e\u003c\/li\u003e\n\u003cli style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cstrong\u003eDang Gui (Angelica Tang Kuei) - Dong Quai \/ Chinese Angelica Root:\u003c\/strong\u003e Tonifies and nourishes heart blood; provides the blood foundation for stable shen residence. Coumarin and ferulic acid anticoagulant effects; monitoring warranted with anticoagulant and antiplatelet medications.\u003c\/span\u003e\u003c\/li\u003e\n\u003cli style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cstrong\u003eWu Wei Zi (Schisandra Fruit) - Schisandra Fruit \/ Five Flavor Fruit:\u003c\/strong\u003e Astringes and consolidates the heart qi and shen; prevents further leakage of shen from yin vacuity. Schisandrin modulates CYP3A4 and CYP2C9 enzymes; monitoring is warranted with hepatically metabolized medications.\u003c\/span\u003e\u003c\/li\u003e\n\u003cli style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cstrong\u003eBai Zi Ren (Biota Seed) - Biota Seed \/ Arborvitae Seed:\u003c\/strong\u003e Nourishes heart blood and calms the shen; one of the formula's three primary shen-calming seeds. Generally well tolerated.\u003c\/span\u003e\u003c\/li\u003e\n\u003cli style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cstrong\u003eSuan Zao Ren (Jujube Seed) - Jujube Seed \/ Sour Date Seed:\u003c\/strong\u003e Nourishes heart and liver blood and calms the shen; most direct shen-nourishing and shen-calming action of the three seeds. Spinosin and jujuboside content with mild calming effects; monitoring warranted in animals on sedatives.\u003c\/span\u003e\u003c\/li\u003e\n\u003cli style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cstrong\u003eRen Shen (Ginseng) - Asian Ginseng Root \/ Korean Ginseng:\u003c\/strong\u003e Tonifies the yuan qi and strengthens the heart qi; provides the qi foundation for shen housing. Ginsenoside content; monitoring warranted with anticoagulants, MAOIs, stimulants, and antidiabetic medications. Do not use with MAOIs.\u003c\/span\u003e\u003c\/li\u003e\n\u003cli style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cstrong\u003eXuan Shen (Scrophularia) - Scrophularia Root \/ Figwort Root:\u003c\/strong\u003e Nourishes kidney yin and clears vacuity heat from the blood level; supports kidney water control of heart fire. Generally well tolerated.\u003c\/span\u003e\u003c\/li\u003e\n\u003cli style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cstrong\u003eDan Shen (Salvia) - Salvia Root \/ Red Sage Root \/ Chinese Sage Root:\u003c\/strong\u003e Activates heart blood, clears heart heat, and calms the shen through blood activation. Tanshinone and salvianolic acid have anticoagulant effects; monitor closely when using warfarin, heparin, aspirin, clopidogrel, or other anticoagulant or antiplatelet medications. Do not use without veterinary review in animals on anticoagulant therapy.\u003c\/span\u003e\u003c\/li\u003e\n\u003cli style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cstrong\u003eFu Ling (Poria) - Poria \/ Hoelen \/ China Root:\u003c\/strong\u003e Tonifies spleen qi, drains dampness, and calms the shen through the heart channel; supports middle jiao for blood generation. Generally well tolerated.\u003c\/span\u003e\u003c\/li\u003e\n\u003cli style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cstrong\u003eYuan Zhi (Polygala) - Polygala Root \/ Senega Snakeroot:\u003c\/strong\u003e Opens the heart orifices, resolves phlegm misting the heart, and strengthens heart-kidney axis communication. GI sensitivity at higher doses; monitoring warranted in animals with gastric conditions.\u003c\/span\u003e\u003c\/li\u003e\n\u003cli style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cstrong\u003eJie Geng (Platycodon) - Platycodon Root \/ Balloon Flower Root:\u003c\/strong\u003e Envoy herb; directs the formula to the heart and upper jiao through ascending and diffusing action. Generally well tolerated at standard doses.\u003c\/span\u003e\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003ch2 style=\"text-align: left;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003ePotential Drug Interactions\u003c\/span\u003e\u003c\/h2\u003e\n\u003cp style=\"text-align: left;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003eRehmannia Settle Anxiety has a significant drug interaction profile given its combination of blood-activating and yin-nourishing herbs. The primary anticoagulant concern is Dan Shen's tanshinone and salvianolic acid content, which can significantly potentiate the effects of warfarin and other anticoagulant and antiplatelet medications; animals on anticoagulant therapy require veterinary review before starting this formula. Dang Gui's coumarin and ferulic acid content adds to the anticoagulant concern, making the combined Dan Shen and Dang Gui presence particularly important to flag for animals on blood-thinning medications. Ren Shen's ginsenoside content warrants monitoring in animals on MAOIs (do not use concurrently), stimulants, antidiabetic medications (combined glucose-lowering effects), and anticoagulants. Wu Wei Zi's schisandrin content modulates hepatic CYP3A4 and CYP2C9 enzyme activity, warranting monitoring in animals on cyclosporine, tacrolimus, chemotherapy agents, anticonvulsants, and other hepatically metabolized medications. Suan Zao Ren's mild calming spinosin and jujuboside content warrants monitoring in animals on sedatives or anxiolytic medications where combined calming effects could be excessive.\u003c\/span\u003e\u003c\/p\u003e\n\u003cp style=\"text-align: left;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003eMedication categories warranting extra caution: anticoagulant and antiplatelet medications (Dan Shen and Dang Gui combined anticoagulant effects - primary concern), MAOIs (Ren Shen - do not use concurrently), antidiabetic medications (Ren Shen glucose-lowering effects), hepatically metabolized medications subject to CYP3A4 and CYP2C9 interaction (Wu Wei Zi schisandrin), and sedatives and anxiolytics (Suan Zao Ren mild calming effects). Because behavioral signs in dogs and cats can have multiple underlying causes, including pain, neurological conditions, and metabolic disease, veterinary assessment is important before attributing the presentation to the heart-kidney yin vacuity pattern. Your authorizing veterinarian will determine appropriateness based on your pet's condition, current medications, tongue quality, pulse character, and clinical assessment of the behavioral signs.\u003c\/span\u003e\u003c\/p\u003e\n\u003cp style=\"text-align: left;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cstrong\u003eVETERINARY AUTHORIZATION REQUIRED: \u003ca href=\"https:\/\/tcvmpet.com\/pages\/get-an-authorization\" rel=\"noopener\" style=\"color: rgb(0, 0, 0);\" target=\"_blank\"\u003eSubmit Your Authorization Request\u003c\/a\u003e or \u003ca href=\"https:\/\/tcvmpet.com\/pages\/schedule-a-consultation\" rel=\"noopener\" style=\"color: rgb(0, 0, 0);\" target=\"_blank\"\u003eRequest a TCVM Telemedicine Consultation\u003c\/a\u003e\u003c\/strong\u003e\u003c\/span\u003e\u003c\/p\u003e\n\u003ch2 style=\"text-align: left;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003eFrequently Asked Questions\u003c\/span\u003e\u003c\/h2\u003e\n\u003ch3 style=\"text-align: left;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003eWhat behavioral signs is Rehmannia Settle Anxiety used for in TCVM?\u003c\/span\u003e\u003c\/h3\u003e\n\u003cp style=\"text-align: left;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003eIn Traditional Chinese Veterinary Medicine, Rehmannia Settle Anxiety is indicated for the heart and kidney yin vacuity pattern with unsettled shen, which manifests behaviorally as nervousness, hyperactivity, and discontentment triggered by environmentally induced stress, including separation, travel, and changes in daily routine. The clinical presentation includes a red or pale-red tongue with little or no coating reflecting yin vacuity; behavioral restlessness and hyperactivity that worsen with stress or environmental change; occasional nighttime waking or difficulty settling from shen disturbance; mild heat signs from yin vacuity heat; and a thin or thin-rapid pulse. This formula is best suited for stress-sensitive animals whose behavioral responses stem from the heart-kidney yin vacuity pattern and is not appropriate for behavioral issues from liver qi stagnation (requiring qi-moving strategies), heart fire blazing from excess (requiring heat-draining strategies), or fear-based responses from different constitutional patterns. Veterinary tongue and pulse examination is important to confirm the heart-kidney yin vacuity pattern before initiating treatment.\u003c\/span\u003e\u003c\/p\u003e\n\u003ch3 style=\"text-align: left;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003eHow is Rehmannia Settle Anxiety administered to dogs and cats?\u003c\/span\u003e\u003c\/h3\u003e\n\u003cp style=\"text-align: left;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003eMix the powder into food at the dose recommended for your pet's species and body weight. All variants are the Canine Blend powder, which is used for both dogs and cats. Because Rehmannia Settle Anxiety contains Dan Shen with significant anticoagulant effects, Ren Shen with MAOI interaction potential, and Wu Wei Zi with hepatic CYP enzyme modulation, veterinary review of all current medications is important before use. In particular, animals on warfarin or other anticoagulant medications, animals on MAOIs, and animals on hepatically metabolized medications require veterinary assessment of interaction potential before initiating this formula. For animals already on sedatives or anxiolytic medications, inform your veterinarian so they can account for the combined calming effects of Suan Zao Ren.\u003c\/span\u003e\u003c\/p\u003e\n\u003ch3 style=\"text-align: left;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003eHow long does it take to see results with Rehmannia Settle Anxiety?\u003c\/span\u003e\u003c\/h3\u003e\n\u003cp style=\"text-align: left;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003eAs a formula addressing the deep heart and kidney yin level, Rehmannia Settle Anxiety requires sustained treatment before the full shen-calming effect is seen. Some improvement in the most responsive behavioral signs (slight reduction in reactivity to environmental stressors, mild improvement in settling ability) may be seen within 3 to 5 weeks as the formula's shen-calming seeds (Suan Zao Ren, Bai Zi Ren) and qi-astringing herb (Wu Wei Zi) begin to consolidate the shen. More sustained improvement in the underlying nervousness and hyperactivity pattern, reflecting meaningful replenishment of the heart-kidney yin and heart blood, typically requires 6 to 12 weeks of consistent use as the yin-nourishing herbs rebuild the constitutional yin reserves. In animals with chronic or severe heart-kidney yin vacuity, long-term maintenance use under veterinary supervision is often appropriate. Your authorizing veterinarian will monitor tongue quality, pulse character, and behavioral signs throughout.\u003c\/span\u003e\u003c\/p\u003e\n\u003ch3 style=\"text-align: left;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003eCan Rehmannia Settle Anxiety be used alongside other calming supplements?\u003c\/span\u003e\u003c\/h3\u003e\n\u003cp style=\"text-align: left;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003eCombining Rehmannia Settle Anxiety with other calming supplements or medications requires veterinary guidance because of the formula's significant drug interaction profile. The primary concern with combination use is the anticoagulant interaction risk from Dan Shen and Dang Gui when combined with other blood-thinning supplements (fish oil at high doses, vitamin E, nattokinase) or medications. Combining with sedative medications or anxiolytic drugs requires veterinary monitoring of combined calming effects given Suan Zao Ren's mild sedative-like activity. Combining with other adaptogenic supplements containing ginseng or similar ginsenoside-containing herbs requires review of Ren Shen's interaction profile. Within the TCVM framework, Rehmannia Settle Anxiety is specifically formulated for the heart-kidney yin vacuity pattern and works most effectively when the correct pattern has been confirmed; combining with formulas addressing different patterns (liver qi stagnation, heart fire) without veterinary guidance may not provide additional benefit and could create unbalanced therapeutic effects. Your authorizing veterinarian will provide guidance on appropriate combination strategies based on your pet's complete clinical picture.\u003c\/span\u003e\u003c\/p\u003e"}