More Help for Dogs Suffering from Cushing's Disease
Active Ingredients per tablet: Melatonin 3mg
Inactive ingredients: Dicalcium phosphate, liver (desiccated and defatted), roast beef flavor, magnesium stearate, stearic acid, silicon dioxide.
120 Chewable Tablets, 120 3 mg servings.
Each bottle contains 120 chewable tablets of 3 mg human-grade melatonin in a beef liver flavor that dogs love!
Our K9 Select brand melatonin supplements for dogs are carefully formulated to:
Promote a natural sleep-wake cycle
Provide natural hormone support
Promote relaxation, calm and comfort
Support overall health – promote normal thirst and urination
Daily use promotes normal skin and coat health
In humans, dogs, and other animals, melatonin plays an important role in the regulation of the sleep-wake cycle. Melatonin is naturally produced by the body in the pineal system. In healthy animals, peak production of melatonin naturally occurs after sunset. Melatonin signals to the body both time of day and season (length of night). However natural production decreases as we and our pets age. This is one reason older people and pets find it difficult to get quality sleep or to sleep for as many hours as when we were younger.
Supplementing with melatonin can be highly beneficial, as melatonin is a well-known antioxidant useful in regulating hormones and may reduce stress and anxiety.
Melatonin decreases sex hormone secretion, modulates aromatase activity, and inhibits cortisol production. It has also been shown in some animal models to inhibit androgen production and ovarian activity.
Melatonin’s anti-estrogenic properties have been extensively studied.
Melatonin acts in several ways to limit estrogen production and/or activities, including by interfering with estrogen receptor activities, downregulating estrogen expression during transcription, reducing estrogen receptor sensitivity, and inhibiting the expression of key enzymes (like aromatase) involved in estrogen production.
In addition, melatonin has been shown not only to inhibit cortisol itself, but also the chemical (ACTH) that signals the adrenal gland to produce cortisol.
Studies have shown melatonin can reduce symptoms of stress in canines, including refusal to eat, excessive pacing or panting, whimpering, and licking. Melatonin may also help reduce aggressive behavior in dogs. Because the body responds to stress by producing additional cortisol, the reduction in stress, anxiety and aggression that results from melatonin supplementation may have a secondary effect (beyond the direct effects noted above) of lowering cortisol levels.
The University of Tennessee College of Veterinary Medicine recommends, and the late Dr. Jack Oliver, DVM, former Chairman of UTK’s Veterinary Endocrinology Department, recommended:
3 mg of melatonin (1 tablet) every 12 hours for dogs under 30 lbs.
6 mg of melatonin (2 tablets) every 12 hours for dogs over 30 lbs.
1 mg of melatonin (you may cut the tablet in half) every 12 hours may be recommended for dogs 10 lbs. or less, or for those who want to give their dogs very low doses of melatonin.
Melatonin may also help anxious dogs by reducing stress hormone levels. For this use, give 1 serving 30 minutes before stressful event.
Note: Always consult your physician or veterinarian before giving melatonin to your dog. For treatment of dogs, you should not use a rapid release melatonin or a timed-release melatonin. Use only regular melatonin. All of our melatonin products fit these criteria.
Can you please tell me where this is manufactured?
Thank you for your question! All Lignans products are manufactured in the USA. Thank you for supporting Traditional Chinese Veterinary Medicine!
Relieved to be able to have confidence in treatment for atypical cushings! Ordering to delivery was quick and efficient!
Ordered these to hopefully help treat Alopecia X. Darling doggie loves to munch them. Keeping our fingers crossed for good outcomes in combo with the HGR Lignans.
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