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Herbsmith Rx Chai Hu Jia Long Gu Mu Li San is a classical Chinese herbal formula recommended by holistic veterinarians to unblock the three yang stages, calm and sedate the spirit, clear depressive fire harassing the heart, and address the complex pattern of simultaneous exterior-interior involvement with spirit disturbance in dogs, cats, and horses. Also known as Bupleurum, Dragon Bone and Oyster Shell Powder, Calm Dragon Formula, and Bupleurum D Formula, Chai Hu Jia Long Gu Mu Li San is derived from the classical Shang Han Lun formula and is indicated for the three yang stages disorder pattern in which pathogenic factors have penetrated beyond the exterior into multiple levels simultaneously, generating the characteristic combination of spirit restlessness and agitation, chest oppression and palpitations, depressive fire harassing the heart spirit, and the underlying three yang stage involvement that prevents simple exterior-releasing or interior-clearing strategies from resolving the pattern. The eleven-ingredient formula addresses this complex pattern through four simultaneous therapeutic strategies: releasing the shaoyang and harmonizing the exterior-interior (Chai Hu, Huang Qin, Ban Xia, Sheng Jiang, Da Zao), calming and sedating the spirit through heavy mineral and shell substances (Long Gu, Mu Li), warming and unblocking the yangming and taiyang levels and supporting the yang (Gui Zhi, Fu Ling, Ren Shen), and purging depressive heat from the interior (Da Huang). Well suited for dogs, cats, and horses presenting with the three yang stages disorder pattern with spirit disturbance, characterized by restlessness, agitation, or anxious behavior; chest oppression or palpitations; insomnia or disturbed sleep; a wiry pulse reflecting shaoyang involvement; and the complex mixed exterior-interior presentation that resists single-strategy treatment. Available as a concentrated powder mixed into food; dogs and cats use the Canine Blend, while horses use the Equine/Horse Blend. Dosing varies by species and body weight, and your authorizing veterinarian will provide specific guidance.
VETERINARY AUTHORIZATION REQUIRED: Submit Your Authorization Request or Request a TCVM Telemedicine Consultation
If the horse initially refuses, start with a small amount mixed into grain and gradually increase, or as directed by your veterinarian. Most horses will readily accept the herbs in their grain. The formula contains Da Huang with purgative action; do not use in animals with diarrhea or significant spleen yang vacuity without explicit veterinary guidance.
Active Ingredients: Chai Hu (Radix Bupleuri), Huang Qin (Radix Scutellariae), Ban Xia (Rhizoma Pinelliae Ternatae), Ren Shen (Radix Ginseng), Sheng Jiang (Rhizoma Zingiberis Officinalis Recens), Gui Zhi (Ramulus Cinnamomi Cassiae), Fu Ling (Sclerotium Poriae Cocos), Long Gu (Os Draconis), Mu Li (Concha Ostreae), Da Huang (Radix et Rhizoma Rhei), Da Zao (Fructus Zizyphi Jujubae)
Inactive Ingredient: Flaxseed
VETERINARY AUTHORIZATION REQUIRED: Submit Your Authorization Request or Request a TCVM Telemedicine Consultation
Chai Hu Jia Long Gu Mu Li San is an eleven-ingredient formula (in this preparation) organized around four therapeutic strategies: shaoyang harmonizing and exterior-interior release (Chai Hu, Huang Qin, Ban Xia, Sheng Jiang, Da Zao), spirit calming through mineral and shell substances (Long Gu, Mu Li), yang support and taiyang unblocking (Gui Zhi, Fu Ling, Ren Shen), and yangming interior heat purging (Da Huang):
Chai Hu Jia Long Gu Mu Li San contains shaoyang-harmonizing and heat-clearing herbs, including Chai Hu and Huang Qin, qi-tonifying Ren Shen, purgative Da Huang, and calcium-containing mineral and shell ingredients (Long Gu and Mu Li), which warrant consideration when reviewing medications. Pets taking prescription medications should use this formula under veterinary supervision because herb-drug interaction research in dogs and cats is limited. Horses taking prescription medications should also have their veterinarian review the formula before use. Ask the veterinarian whether medication timing needs adjustment because of the mineral ingredients.
Medication categories warranting extra caution include medications processed by the liver, anticoagulant or antiplatelet medications, blood glucose-lowering medications, cardiovascular medications, immunosuppressive medications, CNS-modulating medications, and medications whose absorption is affected by calcium. This formula is contraindicated in animals with diarrhea or significant spleen yang vacuity due to Da Huang's purgative action. Your authorizing veterinarian can determine appropriateness based on your animal's condition, current medications, and laboratory results, together with confirmation of the three yang stages disorder with spirit disturbance through tongue, pulse, and behavioral and clinical assessment.
VETERINARY AUTHORIZATION REQUIRED: Submit Your Authorization Request or Request a TCVM Telemedicine Consultation
In Traditional Chinese Veterinary Medicine, Chai Hu Jia Long Gu Mu Li San is indicated for the three yang stages disorder pattern with depressive fire harassing the heart spirit. The clinical presentation centers on restlessness, agitation, or anxious behavior reflecting the spirit disturbance; chest oppression or palpitations; disturbed sleep or insomnia; the complex mixed exterior-interior signs of three yang stage involvement; and a wiry pulse reflecting shaoyang constraint alongside the spirit disturbance signs. This formula is suited for animals whose behavioral disturbance (anxiety, restlessness, agitation) occurs alongside physical signs of the three yang disorder pattern, not for simple behavioral issues without the accompanying TCVM pattern signs. Your authorizing veterinarian will confirm the three yang stages disorder pattern through comprehensive tongue and pulse examination and behavioral and clinical assessment.
Mix the powder into food or grain. Dogs and cats use the Canine Blend. For dogs under 30 lbs, give ½ tsp twice daily, or as directed by your veterinarian. For dogs 30-80 lbs, give 1 tsp twice daily, or as directed by your veterinarian. For dogs 80-120 lbs, give 1½ tsp twice daily, or as directed by your veterinarian. For dogs over 120 lbs, give 2 tsp twice daily, or as directed by your veterinarian. For cats, give ¼ tsp twice daily, or as directed by your veterinarian.
Horses use the Equine/Horse Blend. For a 1,000 lb horse, give two tablespoons twice daily, or as directed by your veterinarian. Continue the initial schedule for 20 days, or as directed by your veterinarian. Then give two tablespoons once daily in grain, or as directed by your veterinarian. If the horse initially refuses, start with a small amount mixed into grain and gradually increase, or as directed by your veterinarian. Comprehensive veterinary review of all current medications is required before use. The formula contains Da Huang (rhubarb root) with purgative action; do not use in animals with diarrhea or significant spleen yang vacuity without explicit veterinary guidance.
As a formula addressing a complex pattern involving multiple yang stages and spirit disturbance, response timing depends on the pattern's chronicity and depth. Early improvement in the most acute spirit disturbance signs (reduced restlessness, decreased agitation, improved behavioral ease) may be seen within 1 to 3 weeks as the formula's spirit-calming mineral herbs and shaoyang-harmonizing herbs begin addressing the pattern. Improvement in pulse quality (wiry toward smoother) and the more chronic behavioral and physical signs of the three yang disorder pattern typically require 3 to 6 weeks. Chronic or deeply established patterns may require 2 to 4 months of treatment, or as directed by your veterinarian. Your authorizing veterinarian will monitor pulse quality, behavioral signs, and clinical presentation throughout the treatment course.
Chai Hu Jia Long Gu Mu Li San is a TCVM pattern-specific formula indicated for the three yang stages disorder with depressive fire harassing the heart spirit; it is not a general anxiolytic or behavioral supplement appropriate for all animals with anxiety or behavioral changes. Its appropriateness depends entirely on whether the animal's presentation matches the specific TCVM pattern, including the shaoyang signs (alternating patterns, chest and hypochondrial involvement, wiry pulse), the spirit disturbance signs (restlessness, agitation, insomnia), and the complex exterior-interior presentation. Animals with behavioral changes from other TCVM patterns (heart blood vacuity, liver blood vacuity, kidney yin vacuity, liver qi stagnation) require different formulas suited to their specific pattern. Your authorizing veterinarian's tongue and pulse assessment and comprehensive behavioral evaluation will determine whether this formula is the correct match for your animal's specific TCVM presentation.
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