Herbsmith Rx Jie Jie Wan is a classical Chinese herbal formula recommended by holistic veterinarians to clear blood heat and support normal urinary flow in dogs, cats, and horses. Indicated for difficult urination due to blood heat and blood strangury, it clears heat at the blood level, promotes normal urinary flow, resolves damp-heat and blood stasis obstructing the urinary tract, and tonifies qi to support the formula's strong clearing and draining actions throughout the treatment course. A twelve-herb formula addressing the blood heat and blood strangury pattern from five simultaneous therapeutic angles, Jie Jie Wan combines a urinary damp-heat-clearing and diuresis-promoting group, a blood-heat-clearing and blood-cooling group addressing the blood heat component of the strangury pattern, the classical E Zhu and San Leng paired combination for blood and qi stasis breaking in the urinary tract, Yan Hu Suo for qi stagnation and urinary urgency and stiffness, and Huang Qi to tonify the qi and prevent the formula's sustained clearing and draining action from overburdening the righteous qi. Well suited for dogs, cats, and horses presenting with blood heat and blood strangury, characterized by difficult, scanty, urgent, or dark urination from blood heat accumulation in the bladder, possible blood-tinged urine reflecting the blood heat injuring the blood vessels in the urinary tract, a red tongue with a yellow coating reflecting the blood heat and damp-heat accumulation, and a rapid and wiry pulse. Available as a concentrated powder mixed into food; cats and dogs use the Canine Blend, while horses use the Equine/Horse Blend. Dosing varies by species and body weight, and your authorizing veterinarian will provide specific guidance.
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What It Supports
- Blood heat clearance and blood-level heat resolution as the root treatment for blood strangury: Clears heat from the blood level to address the blood heat that is the defining pathological mechanism of the blood strangury pattern, using Da Huang's strong blood-heat-clearing and blood-cooling action alongside Tu Yin Chen's heat-resolving and damp-heat-draining action to address the blood heat at its source, cooling the blood to stop the heat from injuring the blood vessels in the urinary tract and restore normal blood circulation through the bladder and urinary structures.
- Urinary damp-heat clearance and normal urinary flow support through five coordinated diuretic and channel-clearing herbs: Clears damp-heat from the bladder and promotes normal urinary flow using Shi Wei, Jin Qian Cao, Hai Jin Sha, Che Qian Zi, and Tong Cao together, providing comprehensive damp-heat clearance and urinary tract channel-opening action from five herbs that collectively address the damp-heat obstruction of the urinary tract at different levels and through different mechanisms, supporting normal urinary flow and clear urine production that the blood heat and damp-heat accumulation has obstructed.
- Blood stasis and qi stagnation resolution in the urinary tract through the E Zhu and San Leng paired combination: Breaks up the blood stasis and qi stagnation that accumulate in the urinary tract as a consequence of the prolonged blood heat and damp-heat obstruction, using the classical E Zhu and San Leng paired combination, which together provide the strongest blood and qi stasis-breaking action in the Chinese materia medica, to dissolve the established stasis in the urinary tract channels and restore normal qi and blood flow through the bladder and associated structures.
- Qi support and righteous qi protection during sustained clearing and draining treatment: Tonifies the qi using Huang Qi to protect the righteous qi from the overburdening effects of the formula's multiple strong clearing, draining, and stasis-breaking herbs, ensuring the treatment course proceeds without progressively depleting the qi that the animal needs to maintain normal organ function and immune competence alongside the blood heat and damp-heat clearance.
TCVM Principles
- Primary action - blood strangury treatment through the five-group strategy of blood heat clearance, damp-heat draining, blood and qi stasis breaking, qi stagnation regulation, and qi tonification: Addresses difficult urination from blood heat and blood strangury through five simultaneous herb groups that together treat the blood heat root, the damp-heat accumulation in the bladder, the blood and qi stasis obstruction in the urinary tract channels, the qi stagnation component of the urinary urgency and stiffness, and the righteous qi protection needed to sustain the strong clearing treatment. The blood-heat-clearing group (Da Huang, Tu Yin Chen) addresses the blood heat that is the defining root mechanism of the blood strangury pattern, cooling the blood and clearing the heat before it can further injure the blood vessels and generate additional blood-tinged urine. The urinary damp-heat-clearing group (Shi Wei, Jin Qian Cao, Hai Jin Sha, Che Qian Zi, Tong Cao) clears the damp-heat accumulation in the bladder and urinary tract, promotes diuresis to flush the heat and dampness from the urinary system, and opens the urinary channels to restore normal urinary flow. The blood and qi stasis-breaking group (E Zhu, San Leng) breaks up the established blood stasis and qi stagnation in the urinary tract that the blood heat and damp-heat obstruction has created, using the two strongest stasis-breaking herbs in the materia medica as a classic paired combination to dissolve the stasis that the damp-heat alone cannot resolve. Yan Hu Suo moves qi stagnation and addresses urinary urgency and stiffness from qi obstruction. Huang Qi tonifies the qi and prevents the depletion from the formula's strong draining action. Gan Cao harmonizes the formula and moderates the harsh draining and stasis-breaking action of Da Huang and the E Zhu and San Leng pairing.
- Secondary action - the E Zhu and San Leng paired combination as the classical blood and qi stasis-breaking pair and its specific role in urinary strangury formulas: E Zhu and San Leng are the two most powerful blood and qi stasis-breaking herbs in the Chinese materia medica and are almost always used together in classical formulas requiring strong stasis-breaking action, because they provide mutually reinforcing blood stasis and qi stasis-breaking coverage that neither herb achieves as effectively alone: San Leng is considered stronger for breaking blood stasis with qi stagnation while E Zhu is considered stronger for breaking qi stagnation with blood stasis, the two herbs together providing complete blood and qi stasis dissolution that is the defining feature of this herb pairing. In Jie Jie Wan, the E Zhu and San Leng pairing addresses the blood stasis layer of the blood strangury pattern that the damp-heat-clearing herbs alone cannot resolve, reflecting the classical clinical understanding that prolonged blood heat and damp-heat accumulation in the urinary tract invariably creates secondary blood stasis as the heat obstructs and desiccates the blood in the affected channels, and that this blood stasis must be directly broken rather than simply cleared alongside the damp-heat.
Available Forms
- Powder - Canine Blend (for dogs and cats): Available in 75 g, 150 g, 500 g, 900 g, and 1200 g sizes; mix into food at the recommended dose for your pet's weight. Cats and dogs both use this blend.
- Powder - Equine/Horse Blend (for horses only): Available in 150 g, 500 g, 900 g, and 1200 g sizes; mix into grain at the recommended dose for your horse.
Suggested Use
For Dogs (Canine Blend Powder):
- Under 30 lbs: ½ tsp twice daily, or as prescribed
- 30-80 lbs: 1 tsp twice daily, or as prescribed
- 80-120 lbs: 1½ tsp twice daily, or as prescribed
- Over 120 lbs: 2 tsp twice daily, or as prescribed
For Cats (Canine Blend Powder): ¼ tsp twice daily, or as prescribed
For Horses (Equine/Horse Blend, 1,000 lb horse): Two tablespoons twice daily for 20 days, then two tablespoons once daily in grain. If the horse initially refuses, start with a small amount mixed into grain and gradually increase until the horse is accustomed to the taste. Most horses will readily accept the herbs in their grain.
Ingredients
Active Ingredients: Shi Wei (Folium Pyrrosiae), Jin Qian Cao (Herba Lysimachiae), Huang Qi (Radix Astragali Membranacei), E Zhu (Rhizoma Curcumae Ezhu), San Leng (Rhizoma Sparganii Stoloniferi), Tong Cao (Medulla Tetrapanacis Papyriferi), Da Huang (Radix et Rhizoma Rhei), Tu Yin Chen (Herba Artemisiae Scopariae), Che Qian Zi (Semen Plantaginis), Yan Hu Suo (Rhizoma Corydalis Yanhusuo), Hai Jin Sha (Spora Lygodii Japonici), Gan Cao (Radix Glycyrrhizae Uralensis)
Inactive Ingredient: Flaxseed
VETERINARY AUTHORIZATION REQUIRED: Submit Your Authorization Request or Request a TCVM Telemedicine Consultation
Active Ingredient TCVM Actions
Jie Jie Wan is a twelve-herb formula for difficult urination due to blood heat and blood strangury, organized into five herb groups: blood heat clearance, urinary damp-heat draining and diuresis promotion, blood and qi stasis breaking, qi stagnation regulation, and qi tonification, with Gan Cao harmonizing the formula:
- Shi Wei (Folium Pyrrosiae) - Pyrrosia Leaf / Stone Reed Leaf: Clears heat, promotes diuresis, opens the urinary channels, and cools the blood; the principal urinary damp-heat-clearing herb at the highest proportion, providing the primary channel-opening and damp-heat-draining action that addresses the damp-heat obstruction in the bladder and urinary tract, cooling the blood heat in the urinary structures and promoting the diuresis that flushes the accumulated damp-heat from the system. Shi Wei has a classical affinity for the blood-strangury pattern and is the lead herb of choice for blood heat presenting in the urinary tract.
- Jin Qian Cao (Herba Lysimachiae) - Lysimachia / Gold Coin Grass: Clears heat, promotes diuresis, expels damp-heat from the urinary tract, and has a classical reputation for supporting the passage of urinary tract congestion; the second major urinary damp-heat-clearing herb that provides additional diuresis and damp-heat-draining coverage alongside Shi Wei, specifically addressing the accumulation and congestion in the urinary channels that the damp-heat and blood heat obstruction creates, and supporting the normal urinary flow restoration that is the formula's primary clinical goal.
- Huang Qi (Radix Astragali Membranacei) - Astragalus Root / Milk Vetch Root: Tonifies the spleen and lung qi, raises the yang, and consolidates the exterior; the qi-tonifying herb that protects the righteous qi from the overburdening effects of the formula's multiple strong heat-clearing, dampness-draining, and stasis-breaking herbs, ensuring the sustained treatment course does not progressively deplete the qi that the animal needs for normal organ function and recovery, and supporting the spleen's role in transforming and transporting fluids throughout the treatment course.
- E Zhu (Rhizoma Curcumae Ezhu) - Zedoary Rhizome / Curcuma Rhizome: Breaks blood stasis, moves qi stagnation, and dissolves accumulations; the first herb of the classical E Zhu and San Leng paired combination, providing strong qi stagnation-breaking action with simultaneous blood stasis-breaking coverage, addressing the qi stagnation layer of the urinary tract obstruction that has developed as a consequence of the prolonged blood heat and damp-heat accumulation. E Zhu's qi stagnation-breaking emphasis complements San Leng's blood stasis-breaking emphasis in the classical paired combination relationship.
- San Leng (Rhizoma Sparganii Stoloniferi) - Sparganium Rhizome / Bur Reed Rhizome: Breaks blood stasis, moves qi, and dissolves accumulations; the second herb of the classical E Zhu and San Leng paired combination, providing the strongest blood stasis-breaking action of the pair, dissolving the established blood stasis in the urinary tract channels that the damp-heat-clearing herbs alone cannot address. San Leng's blood stasis-breaking emphasis and E Zhu's qi stagnation-breaking emphasis together provide complete blood and qi stasis dissolution in the obstructed urinary tract, with the two herbs mutually reinforcing each other's stasis-breaking action through their classical paired combination relationship.
- Tong Cao (Medulla Tetrapanacis Papyriferi) - Rice Paper Plant Pith / Tetrapanax Pith: Promotes diuresis, clears heat, opens the urinary channels, and promotes lactation; the channel-opening and diuresis-promoting herb that specifically opens the urinary channels and promotes the downward movement of fluids through the urinary tract, complementing Shi Wei and Jin Qian Cao's primary damp-heat-draining action with additional channel-opening and fluid-moving coverage that ensures the damp-heat and blood heat being cleared by the formula's primary herbs has a clear route of exit through the urinary system.
- Da Huang (Radix et Rhizoma Rhei) - Rhubarb Root and Rhizome: Drains heat, purges accumulations, clears blood heat, and invigorates the blood; the primary blood-heat-clearing and heat-draining herb that addresses the blood heat root of the strangury pattern directly, cooling the blood and clearing the accumulated heat from the blood level before it can further injure the blood vessels in the urinary tract. Da Huang's purgative action also provides a secondary route of heat elimination through the bowels alongside the primary urinary route of the formula's diuretic herbs, ensuring the blood heat is cleared through two channels simultaneously. Gan Cao moderates Da Huang's harsh draining action during the sustained treatment course.
- Tu Yin Chen (Herba Artemisiae Scopariae) - Scoparia Wormwood Herb / Capillary Artemisia: Clears damp-heat, resolves toxins, and promotes urinary flow; the damp-heat-resolving and toxin-clearing herb that addresses the damp-heat component of the blood strangury pattern from the liver and gallbladder angle, clearing the damp-heat that has accumulated in the urinary system through its affinity for damp-heat conditions in the lower jiao and providing additional heat-resolving and toxin-clearing coverage alongside Da Huang's blood-heat-clearing action.
- Che Qian Zi (Semen Plantaginis) - Plantago Seed / Plantain Seed: Promotes diuresis, clears heat, clears the eyes, and stops coughing; the diuretic and heat-clearing herb that promotes the separation of clear and turbid fluids through the urinary system, increasing urinary output and clearing heat from the bladder through its strong diuretic action, and contributing to the formula's overall strategy of flushing the blood heat and damp-heat obstruction from the urinary tract through increased and normalized urinary flow.
- Yan Hu Suo (Rhizoma Corydalis Yanhusuo) - Corydalis Rhizome /延胡索: Invigorates the blood, moves qi, and alleviates stiffness and urgency from qi stagnation; the qi-moving and stagnation-relieving herb that addresses the urinary urgency, stiffness, and difficult flow from qi stagnation in the urinary tract alongside the blood heat and damp-heat clearance, providing the formula's direct qi stagnation relief in the affected channels and complementing E Zhu and San Leng's stronger stasis-breaking action with a more targeted qi-moving and stagnation-relieving function in the urinary tract structures.
- Hai Jin Sha (Spora Lygodii Japonici) - Lygodium Spore / Japanese Climbing Fern Spore: Clears damp-heat from the urinary tract and promotes urinary flow; the urinary damp-heat-clearing herb with a specific classical affinity for clearing damp-heat and supporting normal urinary flow in the bladder and urinary channels, providing additional damp-heat-clearing and diuresis-promoting coverage as the fifth member of the formula's urinary damp-heat-clearing group alongside Shi Wei, Jin Qian Cao, Tong Cao, and Che Qian Zi, ensuring comprehensive damp-heat clearance from the full scope of the urinary tract channels.
- Gan Cao (Radix Glycyrrhizae Uralensis) - Licorice Root: Tonifies the spleen qi, clears heat, resolves toxins, and harmonizes the formula; the harmonizing herb at the smallest proportion, moderating the harsh draining and stasis-breaking actions of Da Huang, E Zhu, and San Leng to prevent them from causing secondary discomfort or qi injury during the sustained treatment course, clearing residual heat and toxins alongside the formula's primary heat-clearing herbs, and harmonizing the interactions between the formula's twelve herbs to ensure the overall therapeutic strategy proceeds smoothly and without creating secondary imbalances from the combined strong clearing and breaking action.
Potential Drug Interactions
Jie Jie Wan contains Da Huang (rhubarb root), which has strong purgative, blood-heat-clearing, and anticoagulant properties that warrant monitoring in animals on laxatives, blood thinners, anticoagulant or antiplatelet medications, and cardiac glycosides; Da Huang's electrolyte-depleting effects from its purgative action may potentiate the toxicity of cardiac glycosides such as digoxin. E Zhu and San Leng are two of the strongest blood stasis-breaking herbs in the materia medica and together produce a potent anticoagulant and blood-moving effect that warrants careful monitoring in animals on warfarin, heparin, aspirin, or other anticoagulant or antiplatelet medications. Huang Qi may interact with immunosuppressive medications through its immune-modulating properties. Yan Hu Suo contains alkaloids that may interact with medications metabolized by the cytochrome P450 enzyme system and may potentiate sedative medications. The formula's overall character is strongly clearing and draining, and it is indicated specifically for the blood heat and blood strangury pattern confirmed by the veterinarian through tongue, pulse, and urinary assessment; it is not appropriate for urinary conditions without the blood heat pattern presentation, or for animals with significant qi or yang deficiency without concurrent blood heat.
Medication categories warranting extra caution include anticoagulant and antiplatelet medications (Da Huang, E Zhu, San Leng, and Yan Hu Suo's collective blood-moving and anticoagulant effects), cardiac glycosides and digoxin (Da Huang's purgative electrolyte-depleting effects), laxatives (Da Huang's purgative action may cause excessive purging when combined), immunosuppressive medications (Huang Qi's immune-modulating properties), and sedative or CNS medications (Yan Hu Suo's alkaloid content). Your authorizing veterinarian will determine appropriateness based on your animal's condition, current medications, and confirmation of the blood heat and blood strangury pattern through urinary assessment, tongue quality, and pulse examination.
VETERINARY AUTHORIZATION REQUIRED: Submit Your Authorization Request or Request a TCVM Telemedicine Consultation
Frequently Asked Questions
What conditions is Jie Jie Wan used for in TCVM?
In Traditional Chinese Veterinary Medicine, Jie Jie Wan is indicated for difficult urination due to blood heat and blood strangury, presenting with difficult, scanty, urgent, or dark urination from blood heat and damp-heat accumulation in the bladder and urinary tract, possible blood-tinged urine reflecting the blood heat injuring the urinary blood vessels, a red tongue with a yellow coating reflecting the blood heat and damp-heat pattern, and a rapid wiry pulse. It addresses the specific blood heat and blood strangury pattern, where heat at the blood level is the primary driver of urinary difficulty, distinguishing it from other urinary pattern formulas that address cold, qi deficiency, or simple damp-heat without the blood heat component. Your authorizing veterinarian will confirm the blood heat and blood strangury pattern through tongue, pulse, and urinary assessment before beginning the treatment course.
How is Jie Jie Wan administered to dogs, cats, and horses?
Mix the powder directly into food or grain at the dose recommended for your animal's species and body weight. Dogs and cats use the Canine Blend; horses use the Equine/Horse Blend. Dogs and cats receive the formula twice daily; horses receive two tablespoons twice daily for the first 20 days, then once daily for maintenance. If the horse initially refuses, start with a small amount mixed into grain and gradually increase until the horse is accustomed to the taste. Most horses will readily accept the herbs in their grain. Because Jie Jie Wan contains Da Huang (rhubarb root) and the strong stasis-breaking pairing of E Zhu and San Leng, your authorizing veterinarian will review current medications for potential interactions, monitor for signs of excessive purging from Da Huang's purgative action, and provide specific dosing guidance appropriate for the severity of the blood heat and blood strangury pattern.
How long does it take to see results with Jie Jie Wan?
Jie Jie Wan addresses an acute and active blood heat and blood strangury pattern rather than a chronic constitutional deficiency, and improvement in urinary flow, urine color, and urinary urgency is often seen within 1 to 3 weeks of consistent use as the blood heat is cleared and the damp-heat obstruction in the urinary tract is progressively resolved by the formula's five urinary damp-heat-clearing herbs and two blood-stasis-breaking herbs. The speed of response reflects the severity and duration of the blood heat pattern: acute presentations with clear blood heat signs respond more quickly than chronic or complex presentations with established blood stasis in the urinary tract. Your veterinarian will monitor urinary flow, urine color and character, tongue color and coating, and pulse quality throughout the treatment course to confirm the blood heat pattern is resolving and determine when the formula is no longer needed or when a maintenance or transitional formula is appropriate.
Why does a urinary formula contain E Zhu and San Leng, which are typically associated with abdominal masses?
E Zhu and San Leng are the two strongest blood- and qi-stasis-breaking herbs in the Chinese materia medica and are most commonly used in formulas for abdominal masses and accumulations, but their stasis-breaking action is not limited to abdominal presentations. In Jie Jie Wan, they address the blood stasis layer of the blood strangury pattern that develops when prolonged blood heat and damp-heat accumulation in the urinary tract obstruct and desiccate the blood in the affected channels, creating secondary blood stasis that the formula's damp-heat-clearing herbs alone cannot resolve. The classical understanding is that blood strangury involving blood-tinged urine always has a blood stasis component alongside the blood heat, because the heat obstructing the urinary vessels creates local blood stasis in the traumatized vessel walls as a secondary consequence. Treating only the blood heat and damp-heat without addressing this secondary blood stasis leads to incomplete resolution of the obstruction, which is why Jie Jie Wan uses the two most powerful stasis-breaking herbs available to ensure the blood stasis layer is fully dissolved as the formula's primary clearing herbs clear the blood heat and damp-heat.